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We describe the case of a 75-year-old man who was admitted to the hospital after 4\u2005h of stomach aches. A thorough physical examination indicated stomach discomfort and skin discoloration. Laboratory tests revealed thrombocytopenia and elevated lactate dehydrogenase levels. A computed tomography scan of the abdomen revealed that the small intestine wall was thickened, edematous, and necrotic. The necrotic small bowel was surgically removed, revealing many little round, homogenous, and unusual cells in the mesenteric vein. In-situ hybridization revealed that these cells were positive for PAX5, CD20, CD79a, CD10, and BCL2, as well as Epstein-Barr virus-encoded small RNA. After 1 week of hospitalization without treatment, the patient was diagnosed with IVLBCL and died of multiple organ dysfunction syndrome. IVLBCL is a rare illness that affects the small intestine and possibly the gastrointestinal system. It has an insidious start, a fast development, and a dismal prognosis. Knowing its clinicopathologic traits helps in understanding the illness, making an early diagnosis, and preventing rapid worsening.<\/jats:p>","DOI":"10.1177\/10668969231183637","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T03:06:29Z","timestamp":1689044789000},"page":"586-593","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["EBV-Positive Intravascular Large B-Cell Lymphoma of the Small Intestine: A Case Report and Literature Review"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-3459","authenticated-orcid":false,"given":"Chenglong","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Pathology, Kunming Medical University First Affiliated Hospital, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kunming Medical University First Affiliated Hospital, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kunming Medical University First Affiliated Hospital, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kunming Medical University First Affiliated Hospital, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1287363"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4278"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.17037"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12757"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-239422"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2010-0747-RS"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604103141502"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14744"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520924262"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05177.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16081"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29050237"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.19012"},{"key":"e_1_3_2_15_2","first-page":"3610","article-title":"Primary pulmonary intravascular large B-cell lymphoma: a report of three cases and literature review","volume":"15","author":"Zhang Y","year":"2018","unstructured":"Zhang Y, Bi L, Qiu Y, et al. 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