{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:57:28Z","timestamp":1789419448226,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    The WHO classification of esophageal tumors divides esophageal squamous intraepithelial dysplasia into high and low grades, but does not specify its morphological spectrum. Here, the morphological characteristics of various cells were investigated in esophageal squamous (high-grade) dysplasia, and a morphological spectrum and terminology for this lesion were proposed to avoid misdiagnosis. The clinicopathological data of 540 patients with esophageal squamous dysplasia were analyzed retrospectively. According to the unique cytomorphological characteristics of the lesions and the predominant cell type, the esophageal squamous dysplasia was divided into the following morphological groups: classic type (34.6%, 187\/540), basaloid subtype (10.7%, 58\/540), spindle-cell subtype (4.6%, 25\/540), differentiated subtype (48.9%, 264\/540), and verrucous subtype (1.1%, 6\/540). Gender, age, and lesions location did not differ among the subtypes (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&gt;\u20090.05), while Paris classification and lesions diameter significantly differed among the subtypes (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u20090.01). Classic-type cells showed severe atypia. In the basaloid subtype, the cells were small, and resembled basal cells; most of these lesions were of the 0-IIb type with small lesion diameter. In the spindle-cell subtype, the cells and nuclei were spindle-shaped or long and spindle-shaped and arranged in parallel. Differentiated-subtype showed well-to-moderately differentiated cells, and epithelial basal cells were mature. Verrucous-subtype showed well-differentiated cells, and were characterized by verrucous or papillary structures. Esophageal squamous dysplasia has extremely wide morphological spectrum. Awareness of the spectrum of morphological presentations of this lesion, specifically the basaloid subtype, spindle-cell subtype, differentiated subtype, and verrucous subtype, is important for accurate diagnosis.\n                  <\/jats:p>","DOI":"10.1177\/10668969231188906","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T02:22:02Z","timestamp":1690251722000},"page":"692-707","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Morphological Characteristics of Various Cells in Esophageal Squamous Dysplasia: Extremely Wide Morphological Spectrum"],"prefix":"10.1177","volume":"32","author":[{"given":"Weihua","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Pathology, Pingdingshan Medical District (formerly 152 Central Hospital), 989 Hospital of PLA Joint Logistic Support Force, Pingdingshan, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pingdingshan Medical District (formerly 152 Central Hospital), 989 Hospital of PLA Joint Logistic Support Force, Pingdingshan, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinke","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pingdingshan Medical District (formerly 152 Central Hospital), 989 Hospital of PLA Joint Logistic Support Force, Pingdingshan, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Pingdingshan Municipal First People's Hospital, Pingdingshan, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyue","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pingdingshan Medical District (formerly 152 Central Hospital), 989 Hospital of PLA Joint Logistic Support Force, Pingdingshan, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pingdingshan Medical District (formerly 152 Central Hospital), 989 Hospital of PLA Joint Logistic Support Force, Pingdingshan, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-5737","authenticated-orcid":false,"given":"Mulan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"36","volume-title":". WHO classification of tumours, digestive system tumours","author":"Takubo K","year":"2019","unstructured":"Takubo K, Fujii S. Oesophageal squamous dysplasia. In: WHO Classification of Tumours Editorial Board. WHO classification of tumours, digestive system tumours, 5th ed. IARC Press; 2019:36-37.","edition":"5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-016-0551-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-016-0556-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-017-0583-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.32471\/exp-oncology.2312-8852.vol-42-no-4.15437"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112151-20201009-00770"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112151-20210129-00097"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112151-20210825-00603"},{"key":"e_1_3_2_10_2","first-page":"48","volume-title":". WHO classification of tumours, digestive system Tumours","author":"Brown I","year":"2019","unstructured":"Brown I, Fujii S, Kawachi H, Lam ATS. Oesophageal squamous cell carcinoma NOS. In Edited by the WHO Classification of Tumours Editorial Board. WHO classification of tumours, digestive system Tumours, 5th ed. IARC Press; 2019:48-53.","edition":"5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-3011-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00851.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v4.i5.397"},{"issue":"10","key":"e_1_3_2_14_2","first-page":"1084","article-title":"Basaloid squamous cell carcinoma of the esophagus: an immunohistochemical study of 8 cases","volume":"114","author":"Huang Z","year":"2001","unstructured":"Huang Z, Shen Y, Liang Y, Wu X. Basaloid squamous cell carcinoma of the esophagus: an immunohistochemical study of 8 cases. Chin Med J (Engl). 2001;114(10):1084-1088.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2002.01346.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198907000-00001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111561"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112151-20220422-00321"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14395"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000368270"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-02049-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.10.024"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-012-0320-1"},{"issue":"4","key":"e_1_3_2_24_2","first-page":"269","article-title":"The expression of p53, p16, cyclin D1 in esophageal squamous cell carcinoma and esophageal dysplasia","volume":"48","author":"Kim SG","year":"2006","unstructured":"Kim SG, Hong SJ, Kwon KW, et al. The expression of p53, p16, cyclin D1 in esophageal squamous cell carcinoma and esophageal dysplasia. Korean J Gastroenterol. 2006;48(4):269-276.","journal-title":"Korean J Gastroenterol"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02860-2"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.2460852.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2003.02.001"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0873-4"},{"issue":"4","key":"e_1_3_2_29_2","first-page":"685","article-title":"Genetic progression and divergence in superficial esophageal squamous cell carcinoma by loss of heterozygosity analysis","volume":"16","author":"Shima H","year":"2006","unstructured":"Shima H, Hiyama T, Tanaka S, Yoshihara M, Arihiro K, Chayama K. Genetic progression and divergence in superficial esophageal squamous cell carcinoma by loss of heterozygosity analysis. Oncol Rep. 2006;16(4):685-691.","journal-title":"Oncol Rep"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1383-5742(00)00019-3"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.033"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.05.010"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1412-6"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000425"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2301640"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12874"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000683"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0019-RS"},{"issue":"11","key":"e_1_3_2_39_2","first-page":"807","article-title":"Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD vulvar oncology subcommittee","volume":"50","author":"Sideri M","year":"2005","unstructured":"Sideri M, Jones RW, Wilkinson EJ, et al. Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD vulvar oncology subcommittee. J Reprod Med. 2005;50(11):807-810.","journal-title":"J Reprod Med"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231188906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231188906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231188906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:10:06Z","timestamp":1787645406000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231188906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/10668969231188906"],"URL":"https:\/\/doi.org\/10.1177\/10668969231188906","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,24]]}}}