{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:04Z","timestamp":1787646484841,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Synovial lipomatosis is a controversial entity of uncommon intraarticular joint lesions. Most studies focused on radiological findings and surgical resection modalities. Pathologic findings were limited to case reports. Detailed descriptions of the histopathologic features are lacking. We aim to highlight the salient histopathologic features of synovial lipomatosis. We performed a retrospective review study over 15 years retrieving cases of synovial lipomatosis. We found 5 patients (age range: 8-78, average age: 50 years, male to female ratio: 4:1) demonstrating unilateral synovial lipomatosis out of 241 (2.0%) patients with knee joint lesions. Four patients had osteoarthritis. One patient was obese. The resected specimens showed synovial hyperplasia, surface fibrin, hemosiderin pigment, microcalcifications, lymphoplasmacytic infiltrates, lymphoid aggregates, stromal fibrotic, degenerative, and metaplastic alterations shared by other synovitis related changes. Consistent features included abundant adipocytic components, surface adipocytes, prominent large vessel vasculatures, plasma cells, and dense perivascular lymphocytic cuff-like infiltrates. One patient demonstrated superimposed sarcoid-type epithelioid granulomas. A distinct fibrous band separated the lesional tissue from the underlying normal fatty tissue. Synovial lipomatosis predominates in older males with degenerative joint conditions with a second peak in children and adolescents. Obesity is not a risk factor. Some histopathologic features help distinguish synovial lipomatosis from look-alike joint lesions. The findings may suggest an angiolipomatous hamartomatous growth or an exaggerated synovial reaction inducing florid subsynovial stromal proliferative, metaplastic, and degenerative changes. Regardless of its etiopathogenesis, pathologists have a role in confirming the diagnosis and ensuring a complete arthroscopic synovectomy by assessing the presence of the fibrous septa.<\/jats:p>","DOI":"10.1177\/10668969231188908","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T03:44:02Z","timestamp":1689651842000},"page":"708-718","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Synovial Lipomatosis: Histopathologic Features in a Series of Five Cases"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-1214","authenticated-orcid":false,"given":"Badr","family":"AbdullGaffar","sequence":"first","affiliation":[{"name":"Dubai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasnim","family":"Keloth","sequence":"additional","affiliation":[{"name":"Dubai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Abdulrahim","sequence":"additional","affiliation":[{"name":"Dubai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.86839"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2014003"},{"issue":"5","key":"e_1_3_3_4_2","first-page":"1088","article-title":"Synovial lipomatosis (lipoma arborescens) affecting multiple joints in a patient with congenital short bowel syndrome","volume":"29","author":"Siva C","year":"2002","unstructured":"Siva C, Brasington R, Totty W, Sotelo A, Atkinson J. Synovial lipomatosis (lipoma arborescens) affecting multiple joints in a patient with congenital short bowel syndrome. J Rheumatol. 2002;29(5):1088\u20131092.","journal-title":"J Rheumatol"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B2.0800298"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i3.369"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20080201-05"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1604440"},{"issue":"3","key":"e_1_3_3_9_2","first-page":"163","article-title":"Lipoma arborescens (diffuse articular lipomatosis)","volume":"12","author":"Yildiz C","year":"2003","unstructured":"Yildiz C, Deveci MS, Ozcan A, Sara\u00e7o\u011flu HI, Erler K, Basbozkurt M. Lipoma arborescens (diffuse articular lipomatosis). J South Orthop Assoc. 2003;12(3):163\u2013166.","journal-title":"J South Orthop Assoc"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181b1e4fb"},{"issue":"5","key":"e_1_3_3_11_2","first-page":"59","article-title":"Lipoma arborescens \u2013 eyes see what mind knows!","volume":"7","author":"Kulkarni HG","year":"2017","unstructured":"Kulkarni HG, Kulkarni GS, Kulkarni PG. Lipoma arborescens \u2013 eyes see what mind knows!. J Orthop Case Rep. 2017;7(5):59\u201362.","journal-title":"J Orthop Case Rep"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12652"},{"issue":"2","key":"e_1_3_3_13_2","first-page":"210","article-title":"Angiolipomatous mesenchymal hamartoma (angiolipomatosis) of the sigmoid mesocolon","volume":"4","author":"Demir R","year":"2011","unstructured":"Demir R, Schmid A, Hohenberger W, Agaimy A. Angiolipomatous mesenchymal hamartoma (angiolipomatosis) of the sigmoid mesocolon. Int J Clin Exp Pathol. 2011;4(2):210\u2013214.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1980.tb00133.x"},{"key":"e_1_3_3_15_2","first-page":"121","volume-title":"Histology for Pathologists","author":"Maclean F","year":"2020","unstructured":"Maclean F. Joints. In: Mills SE, ed. Histology for Pathologists, 5th ed. Wolters Kluwer; 2020:121, 129-130.","edition":"5"},{"key":"e_1_3_3_16_2","first-page":"234","volume-title":"Mills and Sternberg\u2019s Diagnostic Surgical Pathology","author":"Maclean FM","year":"2022","unstructured":"Maclean FM, Fiona Bonar S. Joints. In: Longacre TA, Greenson JK, Hornick JL, Reuter VE, eds. Mills and Sternberg\u2019s Diagnostic Surgical Pathology, 7th ed. Wolters Kluwer; 2022:234\u2013237, 240, 251-253.","edition":"7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-003-0724-z"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.10.008"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231188908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231188908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231188908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:10:08Z","timestamp":1787645408000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231188908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/10668969231188908"],"URL":"https:\/\/doi.org\/10.1177\/10668969231188908","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]}}}