{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:34:31Z","timestamp":1788957271274,"version":"build-2803163510"},"reference-count":61,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:00:00Z","timestamp":1695513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    Epithelioid glioblastoma (E-GBM) is an exceedingly rare subtype of isocitrate dehydrogenase (IDH)-wildtype glioblastoma, first included in the WHO 2016 classification and characterized by a dominant population of epithelioid cells. Its histological and molecular defining features remain troublesome. The significance of\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    mutations to pathological diagnosis and surgical outcome has drawn increasing attention given their promising potential for future adjuvant therapies. Herein, we describe a unique case of an E-GBM in the atrium of the left lateral ventricle and comprehensively analyze the importance of\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    status in a cohort of 211 E-GBMs from the literature. Our patient was a 40-year-old man with occipital pain. His brain MRI revealed a large intraventricular tumor at the same location as a signal change found 10 years earlier with no additional follow-up. He underwent gross total tumor removal followed by conventional adjuvant treatment. Histopathological diagnosis was consistent with IDH-wildtype E-GBM WHO grade 4 with pleomorphic xanthoastrocytoma-like areas.\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    p.V600 mutation was demonstrated in the tumoral genetic study. In the cohort analyzed, male patients predominated (63%), the median age was 32 years old, and the 5-year survival rate following diagnosis was 4.2%.\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    mutations were found in 60.3% of the tumors overall, with this rate increasing to 78.3% in young adults (19-49 years,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Presence of\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    mutations associated with tumor progression (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.001), the event usually leading to death (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). In conclusion, our study supports the importance of genetic\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    p.V600 mutation analysis because its presence not only points to an E-GBM diagnosis but may also promote tumor progression.\n                  <\/jats:p>","DOI":"10.1177\/10668969231195026","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T01:06:05Z","timestamp":1695603965000},"page":"649-666","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Significance of\n                    <i>BRAF<\/i>\n                    Mutation in the Epithelioid Glioblastoma Subtype: A Systematic Literature Review and a Case Report with a Unique Intraventricular Topography"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-1224","authenticated-orcid":false,"given":"Ruth","family":"Prieto","sequence":"first","affiliation":[{"name":"Puerta de Hierro Majadahonda University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Barrios","sequence":"additional","affiliation":[{"name":"Statistics Department, Computing Center, C.S.I.C., Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Ebrat-Mancilla","sequence":"additional","affiliation":[{"name":"Puerta de Hierro Majadahonda University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro Segovia de Arana (IDIPHISA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Tejerina","sequence":"additional","affiliation":[{"name":"Puerta de Hierro Majadahonda University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,24]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"49","volume-title":"WHO Classification of Tumors. 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