{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:09Z","timestamp":1787646489915,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800459"],"award-info":[{"award-number":["81800459"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diagnosis of Crohn's disease is challenging. This study aims to compare the histological features of Crohn's disease and non-Crohn's disease (other intestinal inflammatory diseases) in surgical specimens to identify a set of histologic features distinguishing Crohn's disease from non-Crohn's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with Crohn's disease (N\u2009=\u2009171) and patients with non-Crohn's disease (N\u2009=\u2009215) diagnosed between 2010 and 2015 who had surgical bowel resection were identified. The frequency of histological features in surgical resection specimens was compared between these two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Univariate analysis revealed that transmural inflammation, subserosal lymphoid aggregates, fissures or sinus-like structures, granulomas or granuloma-like nodules, abnormalities of the enteric nervous system, and mucosa structure alterations (\n                      <jats:italic toggle=\"yes\">muscularis mucosa<\/jats:italic>\n                      thickening or mucosal atrophy with pseudopyloric gland metaplasia) were more frequent in Crohn's disease than non-Crohn's disease cases (\n                      <jats:italic toggle=\"yes\">p\u2009<\/jats:italic>\n                      &lt;\u20090.001 for all). Some of the above histologic features were further grouped as chronic inflammatory change which includes granulomas or granuloma-like nodules, lymphoid aggregates in the\n                      <jats:italic toggle=\"yes\">muscularis propria<\/jats:italic>\n                      or subserosa, fissures or sinus-like structures, and architectural abnormality which is defined as the presence of abnormal enteric nervous system and\/or mucosa structural alterations (\n                      <jats:italic toggle=\"yes\">muscularis mucosa<\/jats:italic>\n                      thickening or mucosal atrophy with pseudopyloric gland metaplasia). A combination of transmural inflammation, chronic inflammatory change, and architectural abnormality had a sensitivity of 92.4% and a specificity of 97.7% for Crohn's disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In surgical bowel resection specimens, a combination of transmural inflammation, chronic inflammatory change, and architectural abnormality help diagnose Crohn's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969231195028","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T05:55:51Z","timestamp":1694843751000},"page":"738-747","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Combination of Pathological Features Identifies Crohn's Disease in Surgical Bowel Resection Specimens"],"prefix":"10.1177","volume":"32","author":[{"given":"Yujuan","family":"Fu","sequence":"first","affiliation":[{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhong","sequence":"additional","affiliation":[{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhong","family":"Fu","sequence":"additional","affiliation":[{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cao","sequence":"additional","affiliation":[{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-0407","authenticated-orcid":false,"given":"Zhinong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2009.12.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.06.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1057-2"},{"key":"e_1_3_2_5_2","unstructured":"Lewin K Riddell RH Weinstein WM et al. Lewin Weinstein and Riddell's gastrointestinal pathology and its clinical implications 2012."},{"key":"e_1_3_2_6_2","unstructured":"Greenson JK. Diagnostic pathology: gastrointestinal 2015."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Odze RD Goldblum JR. Surgical pathology of the GI Tract Liver Biliary Tract and Pancreas. Am J Surg Pathol. 2009;33(10):1581.","DOI":"10.1097\/PAS.0b013e3181adea0e"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.05.016"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.50.2.93"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1514"},{"key":"e_1_3_2_11_2","unstructured":"Fenoglio-Preiser C. Gastrointestinal pathology: an atlas and text. 3rd Ed. 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