{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:23:57Z","timestamp":1793215437775,"version":"4.5.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Epstein-Barr virus (EBV) is a nonhepatotropic virus. It causes mild self-limiting illness characterized by fever, oral ulcer, diarrhea, lymphadenopathy, and hepatosplenomegaly. Rarely it causes acute liver failure (ALF). EBV-related ALF (EBV-ALF) accounts for 0.2% of all ALF cases. The prognosis of EBV-ALF is dismal, and it can affect both immunocompromised and immunocompetent individuals. We performed a partial autopsy on a 30-year-old immunocompetent individual with infectious mononucleosis and ALF. The autopsy showed characteristic histomorphology of EBV-ALF in the form of centrizonal confluent hepatocytic necrosis, portal mixed inflammatory infiltrate, sinusoidal lymphocytosis, numerous hemophagocytic figures, and tissue Epstein-Barr encoded RNA-in situ hybridization (EBER-ISH) positivity. Extensive hemophagocytosis was noted in the liver, spleen, lymph node, and bone marrow. Other features include T-zone expansion of lymph nodes and spleen, interstitial pneumonia pattern in the lungs, and exanthematous skin changes. EBV-DNA polymerase chain reaction from the postmortem blood sample yielded 70,200 copies\/\u00b5L. The index case highlights the uncommon occurrence of EBV-ALF, its histomorphological features, and its putative pathogenesis.<\/jats:p>","DOI":"10.1177\/10668969231195068","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T02:29:57Z","timestamp":1695090597000},"page":"838-844","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Epstein Barr Virus-Related Acute Liver Failure and Hemophagocytosis in an Immunocompetent Individual: An Autopsy Report"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5520-8306","authenticated-orcid":false,"given":"Suvradeep","family":"Mitra","sequence":"first","affiliation":[{"name":"PGIMER"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan Kumar","family":"Hanumanthappa","sequence":"additional","affiliation":[{"name":"PGIMER"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhabrata","family":"Sarkar","sequence":"additional","affiliation":[{"name":"PGIMER"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Bhalla","sequence":"additional","affiliation":[{"name":"PGIMER"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana","family":"Minz","sequence":"additional","affiliation":[{"name":"PGIMER"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha Kanta","family":"Ratho","sequence":"additional","affiliation":[{"name":"PGIMER"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20703"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208937"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3029-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500040612"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2017.08.005"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2022.11.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.14740\/gr718e"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2002.0993"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.825806"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0208-RA"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24052"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231195068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231195068","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231195068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:10:23Z","timestamp":1787645423000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231195068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,18]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/10668969231195068"],"URL":"https:\/\/doi.org\/10.1177\/10668969231195068","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,18]]}}}