{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:03Z","timestamp":1787646483959,"version":"build-2736575974"},"reference-count":52,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["2020-I2M-C&T-B-038"],"award-info":[{"award-number":["2020-I2M-C&T-B-038"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Introduction:<\/jats:italic>\n                    The etiology of esophageal squamous papilloma (ESP) is largely unknown. Previous studies have shown a variable association with human papillomavirus (HPV) with conflicting data. The aim of this study was to further investigate the possible association of HPV in our ESP series using RNA in-situ hybridization (ISH) and compare study groups from the United States of America and China.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    Demographic and clinical data of patients with ESP were retrieved from the University of California Los Angeles (UCLA) (1\/2016-3\/2019) and Peking Union Medical College Hospital (PUMCH) (9\/2014-3\/2019) pathology databases. Hematoxylin and eosin slides were reexamined. Confirmed cases were examined by high- and low-risk HPV RNA ISH.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    For the UCLA cohort, 13\u2005429 upper endoscopies were performed and 78 biopsies from 72 patients were identified as ESP (F:M\u2009=\u200945:27, 66.7%\u2009&gt;\u200945 years). Seventy-four (94.9%) biopsies were designated as polyps or nodules and 46.6% were located in the mid-esophagus. Other abnormal findings included gastroesophageal reflux disease (48.6%), hiatal hernia (38.9%), and esophagitis (36.1%). For the PUMCH cohort, 63\u2005754 upper endoscopies were performed and 73 biopsies from 71 patients were identified as ESP (F:M\u2009=\u200948:23, 71.8%\u2009&gt;\u200945 years). Sixty-four (87.7%) biopsies were designated as polyps or nodules and 57.5% were located in the mid-esophagus. Other abnormal findings included esophagitis (19.7%), and hiatal hernia (8.5%). No features of conventional cytologic dysplasia or viral cytopathic change were found. None of the cases was associated with squamous cell carcinoma, and none showed positive HPV RNA ISH results.\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    No association was found between ESP and active HPV infection in our 2 cohorts. Other etiopathogenetic mechanisms, such as aging, might contribute to the development of these innocent lesions.\n                  <\/jats:p>","DOI":"10.1177\/10668969231195772","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T06:36:17Z","timestamp":1695191777000},"page":"748-757","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Detection of Human Papillomavirus in Squamous Papilloma of the Esophagus"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9338-2463","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"},{"name":"Peking Union Medical College Hospital"},{"name":"Cedars-Sinai Biobank &amp; Research Pathology Resource, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lin","sequence":"additional","affiliation":[{"name":"Geisinger Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ling","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Xue","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","first-page":"1","article-title":"Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papillomavirus","volume":"30","author":"Pantham G","year":"2017","unstructured":"Pantham G, Ganesan S, Einstadter D, et al. 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