{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:12Z","timestamp":1787646492032,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n                    Pineal parenchymal tumors are rare central nervous system tumors that pose diagnostic challenges for surgical pathologists. Due to their paucity, their clinicopathologic features are still being defined. We report an 86-year-old woman with a remote history of breast lobular carcinoma who presented with a 2-month neurologic history that included gait instability, blurry vision, and headaches. Magnetic resonance imaging revealed a lobular, heterogeneously enhancing pineal region mass compressing the aqueduct of Sylvius. A biopsy performed concomitant with endoscopic third ventriculostomy consisted of small sheets of cells with eosinophilic to clear cytoplasm, multipolar processes, and ovoid nuclei with stippled chromatin. Whole exome sequencing revealed a small in-frame insertion (duplication) in exon 4 of\n                    <jats:italic toggle=\"yes\">KBTBD4<\/jats:italic>\n                    (c.931_939dup, p.P311_R313dup\/ p.R313_M314insPRR), which has very recently been reported in 2 pineal parenchymal tumors of intermediate differentiation (PPTID). Additionally, variants of uncertain significance in\n                    <jats:italic toggle=\"yes\">CEBPA<\/jats:italic>\n                    (c.863G\u2009&gt;\u2009C, p.R288P) and\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    (c.655T\u2009&gt;\u2009C, p.S219P) were identified. Although PPTID is considered a disease of young adulthood, review of 2 institutional cohorts of patients with pineal region tumors revealed that 25% of individuals with PPTID were over 65 years of age. In conclusion, PPTID should be considered in the differential diagnosis of pineal region tumors in older adults.\n                  <\/jats:p>","DOI":"10.1177\/10668969231201411","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:07:12Z","timestamp":1697692032000},"page":"962-969","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Pineal Parenchymal Tumor of Intermediate Differentiation in an Octogenarian Contains a Rare\n                    <i>KBTBD4<\/i>\n                    Insertion"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1202-9257","authenticated-orcid":false,"given":"Victoria M.","family":"Jones","sequence":"first","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Kanter","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Russo","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan E.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Tafe","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Zanazzi","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"},{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.780173"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071547"},{"issue":"6","key":"e_1_3_2_4_2","first-page":"5758","article-title":"Pineal region tumors: pathophysiological mechanisms of presenting symptoms","volume":"13","author":"Mavridis IN","year":"2021","unstructured":"Mavridis IN, Pyrgelis ES, Agapiou E, Meliou M. Pineal region tumors: pathophysiological mechanisms of presenting symptoms. Am J Transl Res. 2021;13(6):5758-5766.","journal-title":"Am J Transl Res"},{"key":"e_1_3_2_5_2","volume-title":"Central Nervous System Tumours","author":"World Health Organization Classification of Tumours Editorial Board","year":"2021","unstructured":"World Health Organization Classification of Tumours Editorial Board. Central Nervous System Tumours. International Agency for Research on Cancer; 2021 (WHO classification of tumours series, 5th ed.; vol. 6)."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-01990-5"},{"issue":"3","key":"e_1_3_2_7_2","first-page":"130","article-title":"Role of proliferative marker index and KBTBD4 mutation in the pathological diagnosis of pineal parenchymal tumors","volume":"39","author":"Uchida E","year":"2022","unstructured":"Uchida E, Sasaki A, Shirahata M, et al. Role of proliferative marker index and KBTBD4 mutation in the pathological diagnosis of pineal parenchymal tumors. Brain TumorPathol. 2022;39(3):130-138.","journal-title":"Brain TumorPathol"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010146"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/11795735231160036"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2013.231"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2021.100814"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14153646"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018812"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.01.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2806"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmccrj.cr.2018-0221"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007010200055"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.5414\/NPP27325"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02284-5"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04310-w"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22973"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01066-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00983-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1318-7"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05029-3"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02101-0"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2015.07.032"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz050"},{"issue":"2","key":"e_1_3_2_29_2","first-page":"1","article-title":"Genomic alterations underlying spinal metastases in pediatric H3K27M-mutant pineal parenchymal tumor of intermediate differentiation: case report","volume":"25","author":"Fomchenko EI","unstructured":"Fomchenko EI, Erson-Omay EZ, Kundishora AJ, et al. Genomic alterations underlying spinal metastases in pediatric H3K27M-mutant pineal parenchymal tumor of intermediate differentiation: case report. J Neurosurg Pediatr. 2019; 25(2):1-10.","journal-title":"J Neurosurg Pediatr"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930801)72:3<870::AID-CNCR2820720336>3.0.CO;2-X"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00242.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00389-2"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000565"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2011.01202.x"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231201411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231201411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231201411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:10:28Z","timestamp":1787645428000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231201411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1177\/10668969231201411"],"URL":"https:\/\/doi.org\/10.1177\/10668969231201411","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969231201411\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969231201411\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969231201411\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969231201411\/v1\/review1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,19]]}}}