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Alveolar adenoma was more frequently diagnosed in female patients (80%). The patients ranged in age from 52 to 68. Eighty percent of the patients had symptoms like dyspnea, and shoulder or back pain. Three patients underwent a video-assisted thoracoscopic surgery, while 2 patients underwent a thoracotomy in order to remove the tumor. The tumor was localized within the right upper lobe, right lower lobe, and left lower lobe in 40%, 40%, and 20% of patients, respectively. The tumor size ranged from 14 to 30 mm. A frozen section finding of all 5 tumors reported that the lesion was benign. In all analyzed tumors, immunohistochemical analysis showed positive expression of TTF-1 and pankeratin in surface epithelial cells, and Vimentin positivity and TTF-1 and pankeratin negativity in round stromal cells. Alveolar adenoma should be carefully considered in the differential diagnosis of solitary pulmonary nodules. Complete surgical removal of the lesion is widely used in its primary management.<\/jats:p>","DOI":"10.1177\/10668969231204998","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T02:38:32Z","timestamp":1698633512000},"page":"982-991","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Alveolar Adenoma: A 20-Year Experience at a Western Balkan University Hospital and a Literature Review"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5278-6194","authenticated-orcid":false,"given":"Aleksandra","family":"Lovrenski","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia"},{"name":"Department of Pathology and Molecular Diagnostics, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Gardi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia"},{"name":"Department of Pathology and Molecular Diagnostics, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-7483","authenticated-orcid":false,"given":"Milena","family":"\u0160unjevi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia"},{"name":"Pathology Department, Clinical Center of Vojvodina, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Dragi\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Vu\u010dkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia"},{"name":"Department of Pathology and Molecular Diagnostics, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80092-2"},{"key":"e_1_3_3_3_2","article-title":"CD34 expression in the stromal cells of alveolar adenoma","volume":"913517","author":"De Rosa N","year":"2012","unstructured":"De Rosa N, Maiorino A, De Rosa I, Curcio C, Sellitto C, Amore D. 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