{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:27:12Z","timestamp":1787646432773,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Cribriform morular thyroid carcinoma has been added under tumors of uncertain histogenesis. Its peculiar clinical, histomorphological pattern, and immunohistochemical profile have been proved different from papillary thyroid carcinoma. A 59-year-old female patient had a lesion in the left lobe of the thyroid. Fine needle aspiration cytology was reported as medullary thyroid carcinoma. The total thyroidectomy specimen showed a predominantly solid tumor of size 9.5\u2005cm in the left lobe. Microscopy showed a mixed growth pattern with the dominant cribriform and solid morular area. Nuclear features of papillary carcinoma were not seen. Squamoid morules had nuclear clearing. Marked stromal hyalinization and calcification were noted. Extrathyroidal extension, lymphovascular invasion, and lymph node metastasis were not identified. Immunohistochemically the tumor cells were diffuse and strong nuclear positive for \u03b2-catenin, TTF1, PAX8, estrogen receptor, focal, and weak positivity for CD5. Synaptophysin, calcitonin, thyroglobulin, and CDX2 were negative. We report this rare cribriform morular thyroid carcinoma case with its associated uncommon histological and immunohistochemical features.<\/jats:p>","DOI":"10.1177\/10668969231206572","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:15:28Z","timestamp":1698286528000},"page":"1009-1016","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Cribriform Morular Thyroid Carcinoma: A Rare Case and Associated Uncommon Features"],"prefix":"10.1177","volume":"32","author":[{"given":"Ajit","family":"Sahu","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Shahin","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-4178","authenticated-orcid":false,"given":"Priyansh","family":"Jain","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Sultania","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-6835","authenticated-orcid":false,"given":"Pavithra","family":"Ayyanar","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09707-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0589"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP7ULS0VSISBEB"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0070-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03495-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0261"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-019-00146-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.04.010"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-021-09683-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42047-021-00103-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-011-9174-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-013-9274-7"},{"key":"e_1_3_2_14_2","first-page":"531","article-title":"Cribriform-morular variant of papillary thyroid carcinoma at pediatric age\u2013case report and review of the literature","volume":"57","author":"Brehar AC","year":"2016","unstructured":"Brehar AC, Terzea DC, Ioachim DL, et al. Cribriform-morular variant of papillary thyroid carcinoma at pediatric age\u2013case report and review of the literature. Rom J Morphol Embryol. 2016;57(2):531\u2010537.","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-66-18"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0873-3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12728"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000501097"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2019.1616865"},{"key":"e_1_3_2_20_2","first-page":"339","article-title":"Cytohistology of morule in cribriform-morular variant of papillary thyroid carcinoma","volume":"41","author":"Sakurai K","year":"2019","unstructured":"Sakurai K, Onouchi T, Yamada S, et al. Cytohistology of morule in cribriform-morular variant of papillary thyroid carcinoma. 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Deep molecular insights of a unique case Endocr Pathol. 2023;34(3):342-348.","journal-title":"Endocr Pathol"},{"key":"e_1_3_2_25_2","first-page":"6222432","article-title":"The first case of cribriform-morular thyroid carcinoma and FAP with APC gene mutation in China: a case report and brief review","volume":"2023","author":"Lyu S","year":"2023","unstructured":"Lyu S, Zhong G, Chen H, Li J, Li M. The first case of cribriform-morular thyroid carcinoma and FAP with APC gene mutation in China: a case report and brief review. Case Rep Gastrointest Med. 2023;2023:6222432. 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