{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:30:57Z","timestamp":1787646657503,"version":"build-2736575974"},"reference-count":10,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Describe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational study in which categorized patients according to those with and without parametrial involvement. A descriptive analysis and comparative analysis were performed for associations between parametrial spread and clinical, surgical, and pathology variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed 85 patients, which 18 (21%) had parametrial involvement. Pathology factors associated with parametrial involvement were the endometrioid subtype, grade 3, and variants of poor prognosis (odds ratio (OR) 3.41, 95% CI 1.09-10.64;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.035), myometrial invasion of over 50% (OR 7.76, 95% CI 1.65-36.44;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.009), serosal involvement (OR 17.07, 95% CI 3.87-75.35;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), ovarian metastasis (OR 5.15, 95% CI 1.36-19.46;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.016), positive peritoneal cytology (OR 3.9, 95% CI 1.04-14.77;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.044), and lymph node metastasis (OR 3.4; 95% CI 1.16-9.97;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.026). Five-year disease-free survival was 74% (95% CI 57.4-85.4) for the group without parametrial spread and 50.8% (95% CI 22.7-73.4) for the group with parametrial spread (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001). Similarly, 5-year overall survival was 85.2% (95% CI 67.9-93.6) for the group without parametrial spread and 47.5% (95% CI 8.1-80.2) for the group with parametrial spread (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Factors associated with parametrial involvement were histologies of poor prognosis, tumors affecting uterine serosa, cervix, or spread beyond the uterus. Additionally, parametrial involvement directly affects prognosis by reducing overall survival, disease-free survival and increasing odds for recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969231225773","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T01:59:15Z","timestamp":1708653555000},"page":"1241-1247","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy"],"prefix":"10.1177","volume":"32","author":[{"given":"Salim","family":"Barquet-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Universidad Nacional Autonoma de Mexico"},{"name":"Instituto Nacional de Cancerologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bandala-Jaques","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Delia","family":"Perez-Montiel","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diddier","family":"Prada","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marithe","family":"Mart\u00ednez-Flores","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa A.","family":"Salcedo-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"P\u00e9rez-Plasencia","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Gonzalez-Enciso","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0229-7931","authenticated-orcid":false,"given":"David Cantu-de","family":"Leon","sequence":"additional","affiliation":[{"name":"Direction of Research, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f80a49"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2000.010004313.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0288"},{"issue":"1","key":"e_1_3_3_5_2","article-title":"Pathologic prognostic factors in endometrial carcinoma (other than tumor type and grade)","volume":"38","author":"Singh N","year":"2019","unstructured":"Singh N, Hirschowitz L, Zaino R, et al. Pathologic prognostic factors in endometrial carcinoma (other than tumor type and grade). Int J Gynecol Pathol. 2019;38(Suppl 1):S93-S113.","journal-title":"Int J Gynecol Pathol."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.521"},{"issue":"3","key":"e_1_3_3_7_2","first-page":"241","article-title":"Parametrial spread is a prognostic factor in endometrial carcinoma","volume":"24","author":"Sato R","year":"2003","unstructured":"Sato R, Jobo T, Kuramoto H. Parametrial spread is a prognostic factor in endometrial carcinoma. Eur J Gynaecol Oncol. 2003;24(3-4):241-245.","journal-title":"Eur J Gynaecol Oncol"},{"issue":"2","key":"e_1_3_3_8_2","article-title":"Comparative survival outcomes of uterine papillary serous carcinoma, clear cell carcinoma, grade 3 endometrioid adenocarcinoma, and carcinosarcoma of endometrial cancer in Rajavithi hospital","volume":"99","author":"Prueksaritanond N","year":"2016","unstructured":"Prueksaritanond N, Chantape W. Comparative survival outcomes of uterine papillary serous carcinoma, clear cell carcinoma, grade 3 endometrioid adenocarcinoma, and carcinosarcoma of endometrial cancer in Rajavithi hospital. J Med Assoc Thai. 2016;99(Suppl 2):S75-S83.","journal-title":"J Med Assoc Thai"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.6111"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(79)90079-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-020-01876-x"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231225773","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969231225773","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969231225773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:12:12Z","timestamp":1787645532000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969231225773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,22]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/10668969231225773"],"URL":"https:\/\/doi.org\/10.1177\/10668969231225773","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,22]]}}}