{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:43Z","timestamp":1787646523350,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    Currently, there is no robust evidence demonstrating a clear association between Lynch syndrome and non-malignant breast pathology such as adenomyoepithelioma. We report a case of benign breast adenomyoepithelioma, which after recurrence was associated with ductal carcinoma in-situ (DCIS) in a 41-year-old woman with Lynch syndrome, who lacked significant family history of breast or ovarian cancer. Both, the adenomyoepithelioma and DCIS were found to have nuclear loss of MSH2\/MSH6 by immunohistochemistry, while germline testing confirmed\n                    <jats:italic toggle=\"yes\">MSH2<\/jats:italic>\n                    gene mutation. Concordant loss of MSH2 in both lesions in the context of a\n                    <jats:italic toggle=\"yes\">MSH2<\/jats:italic>\n                    pathogenic variant in this patient with Lynch syndrome illustrates that the benign adenomyoepithelioma behaved as a likely precursor of DCIS. Our report provides a novel perspective that in some patients with Lynch syndrome adenomyoepithelioma may represent a pre-malignant precursor lesion of DCIS.\n                  <\/jats:p>","DOI":"10.1177\/10668969241226704","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:42:16Z","timestamp":1706748136000},"page":"1350-1356","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Benign Adenomyoepithelioma: An Unrecognised Precursor of Ductal Carcinoma in Situ in Patient With Lynch Syndrome"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-0446","authenticated-orcid":false,"given":"Sean SW","family":"Park","sequence":"first","affiliation":[{"name":"The Breast Centre, Gasteshead, Australia"},{"name":"The University of Newcastle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Chan","sequence":"additional","affiliation":[{"name":"Manning Base Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanta","family":"Velaiutham","sequence":"additional","affiliation":[{"name":"The Breast Centre, Gasteshead, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-5088","authenticated-orcid":false,"given":"Ana Cristina","family":"Vargas","sequence":"additional","affiliation":[{"name":"Douglas Hanly Moir Pathology"},{"name":"University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.11.110"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14091"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14380"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00694925"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i29.8864"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i31.9549"},{"key":"e_1_3_3_8_2","volume-title":"StatPearls","author":"Tomlinson-Hansen S","year":"2023","unstructured":"Tomlinson-Hansen S, Khan M, Cassaro S. Breast ductal carcinoma in situ. In StatPearls. StatPearls Publishing Copyright \u00a9 2023, StatPearls Publishing LLC.; 2023."},{"key":"e_1_3_3_9_2","first-page":"521417","article-title":"Adenomyoepithelioma with ductal carcinoma in situ: a case report and review of the literature","volume":"2013","author":"Warrier S","year":"2013","unstructured":"Warrier S, Hwang S, Ghaly M, Matthews A. Adenomyoepithelioma with ductal carcinoma in situ: a case report and review of the literature. 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