{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:01:03Z","timestamp":1788462063819,"version":"build-2803163510"},"reference-count":19,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    Neurofibromatosis type 1 (NF1) is the most common human genetic disease. In these patients, the incidence of malignant peripheral nerve sheath tumors (MPNST) and gastrointestinal stromal tumors (GIST) is increased. A male patient in his forties with neurofibromatosis 1, presented with the coexistence of multiple GISTs located at intestinal and colonic mesentery, MPNST located at his leg and atypical neurofibromatous neoplasm with uncertain biologic potential located at colonic mesentery. By FISH, the MPNST harbored\n                    <jats:italic toggle=\"yes\">CDKN2A<\/jats:italic>\n                    loss and recurred 1 year later. After reresection and radiotherapy, the patient is now disease-free without evidence of disease. Atypical neurofibromatous neoplasm with uncertain biologic potential is a newly defined entity, and it is important to discriminate it from low-grade MPNST, which requires more aggressive treatment methods. To the best of our knowledge, this is the first report describing synchronous GISTs, MPNST, and atypical neurofibromatous neoplasm with uncertain biologic potential developing in a single NF1 patient.\n                  <\/jats:p>","DOI":"10.1177\/10668969241229350","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:25:10Z","timestamp":1706833510000},"page":"1415-1421","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Multiple Gastrointestinal Stromal Tumors, Malignant Peripheral Nerve Sheath Tumor and Atypical Neurofibromatous Neoplasm With Uncertain Biologic Potential Developing in A Single Patient With Neurofibromatosis Type 1 Syndrome"],"prefix":"10.1177","volume":"32","author":[{"given":"Elif","family":"Cerrah","sequence":"first","affiliation":[{"name":"Department of Pathology, Prof. Dr Cemil Ta\u015f\u00e7\u0131o\u011flu \u015e. Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-7042","authenticated-orcid":false,"given":"Cem","family":"\u00c7omuno\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Prof. Dr Cemil Ta\u015f\u00e7\u0131o\u011flu \u015e. 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Gastrointestinal stromal tumors associated with neurofibromatosis 1: a single centre experience and systematic review of the literature including 252 cases. Int J Surg Oncol. 2013;2013:398570. doi: https:\/\/doi.org\/10.1155\/2013\/398570","journal-title":"Int J Surg Oncol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800334"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.17161\/kjm.vol1415071"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.05.010"},{"key":"e_1_3_2_14_2","first-page":"254","volume-title":"Soft tissue and bone tumours","author":"Nielson GP","year":"2020","unstructured":"Nielson GP, Chi P. Malignant peripheral nerve sheath tumour. In: WHO Classification of Tumours Editorial Board, ed. Soft tissue and bone tumours, 5th ed. 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