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It is uncertain whether it represents a hamartoma, choristoma, or a distinct neoplasm, including possibly a variant of mammary-type myofibroblastoma. We report two additional chondrolipomatous lesions of the breast. The lesions had varying histologic and immunohistochemical features similar to myofibroblastoma, including the loss of retinoblastoma (Rb) protein expression in one lesion. Molecular analysis by chromosomal microarray analysis performed on a second lesion did not demonstrate a loss of 13q14 or 16q typical of myofibroblastoma. Our findings further support the concept that at least a subset of breast lesions that historically have been classified as chondrolipoma are related to myofibroblastoma. However, the lack of myofibroblastoma-specific molecular alterations in one lesion suggests chondrolipomas may also have varying origins.<\/jats:p>","DOI":"10.1177\/10668969241231975","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T01:39:37Z","timestamp":1707961177000},"page":"1525-1530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chondrolipoma of the Breast: A Myofibroblastoma Variant or a Distinct Lesion?"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5088-0690","authenticated-orcid":false,"given":"Adrienne A.","family":"Workman","sequence":"first","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Green","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"},{"name":"Geisel School of Medicine at Dartmouth, Hanover, NH, USA"},{"name":"Dartmouth Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Cloutier","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"},{"name":"Geisel School of Medicine at Dartmouth, Hanover, NH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Marotti","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center"},{"name":"Geisel School of Medicine at Dartmouth, Hanover, NH, USA"},{"name":"Dartmouth Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"issue":"3","key":"e_1_3_3_2_2","first-page":"149","article-title":"Benign chondrolipomatous tumor of the human female breast","volume":"101","author":"Kaplan L","year":"1977","unstructured":"Kaplan L, Walts AE. 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