{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:53Z","timestamp":1787646533611,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\u201cTumor-to-tumor metastasis,\u201d an uncommon phenomenon, refers to a primary tumor metastasis into another tumor, with the most frequent donor being lung carcinoma and common recipients being renal cell carcinoma and meningioma. Tumor-to-tumor metastasis occurring in gliomas is rare with less than 20 reports described so far, and that into a glioblastoma is even rarer. We report a 54-year man, diagnosed with glioblastoma, IDH-wildtype, with metastasis of an adenocarcinoma into it. On histomorphology, the glial component was composed of astrocytic cells and showed increased mitosis, microvascular proliferation, and focal necrosis. This was intermingled with an adenocarcinomatous tumor with pleomorphic epithelial cells in glands, nests, and sheets. On immunohistochemistry, the adenocarcinomatous areas were positive for AE1\/AE3 and TTF1 but negative for glial markers, ruling out adenoid glioblastoma. Further cytogenetic analysis showed EGFR amplification in the glial component but not in the adenocarcinoma component, ruling out glioblastoma with true epithelial metaplasia, and supporting the diagnosis of adenocarcinoma metastasis into glioblastoma. Glioblastomas may be susceptible to intratumoral metastasis due to the proliferating leaky vascular channels, however, the short survival of patients with glioblastoma may be responsible for the rarity of this occurrence. The documentation of these tumors is important as they may be important for clinical diagnosis and further treatment and prognosis.<\/jats:p>","DOI":"10.1177\/10668969241231979","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T20:03:45Z","timestamp":1708459425000},"page":"1520-1524","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Glioblastoma with Probable Intratumoral Adenocarcinoma Metastasis: A Rare Report with Review of Literature"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-1011","authenticated-orcid":false,"given":"Aditi","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-6557","authenticated-orcid":false,"given":"Shilpa","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjaya I.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Aster RV Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-2359","authenticated-orcid":false,"given":"Vani","family":"Santosh","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12601"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(87)90568-1"},{"issue":"2","key":"e_1_3_2_5_2","first-page":"151","article-title":"Tumor-to-tumor metastasis of the central nervous system","volume":"24","author":"Erdogan H","year":"2014","unstructured":"Erdogan H, Aydin MV, Tasdemiroglu E. Tumor-to-tumor metastasis of the central nervous system. Turk Neurosurg. 2014;24(2):151-162.","journal-title":"Turk Neurosurg"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23899"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1960.00450050079009"},{"key":"e_1_3_2_8_2","first-page":"206","article-title":"Metastasis of a breast carcinoma to an intracerebral oligodendroglioma","volume":"25","author":"Strang RR","year":"1965","unstructured":"Strang RR. Metastasis of a breast carcinoma to an intracerebral oligodendroglioma. Zentralbl Neurochir. 1965;25:206-210.","journal-title":"Zentralbl Neurochir"},{"key":"e_1_3_2_9_2","volume-title":"Brain tumours: Their biology and pathology","author":"Zulch KJ","unstructured":"Zulch KJ. Brain tumours: Their biology and pathology. 2nd ed. Heinemann; 1965:255.","edition":"2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313027209068950"},{"key":"e_1_3_2_11_2","volume-title":"Pathology of turnouts of the nervous system","author":"Russell DS","year":"1977","unstructured":"Russell DS, Rubinstein LJ. Pathology of turnouts of the nervous system. 4th Ed. E. Arnold; 1977.","edition":"4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01401684"},{"key":"e_1_3_2_13_2","volume-title":"Metastatic Tumors of the Central Nervous System","author":"Takakura K","year":"1982","unstructured":"Takakura K, Sano K, Hojo S, et al. Metastatic Tumors of the Central Nervous System. Igaku-Shoin; 1982."},{"issue":"13","key":"e_1_3_2_14_2","first-page":"1733","article-title":"A case of metastasis from a colon carcinoma to an intracranial oligodendroglioma","volume":"33","author":"Mizutani H","unstructured":"Mizutani H, Suzuki H, Wakabayashi S, et al. A case of metastasis from a colon carcinoma to an intracranial oligodendroglioma. Gan No Rinsho. 1987 Oct;33(13):1733-1739.","journal-title":"Gan No Rinsho"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.2.256"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.68.5.0811"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01664858"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00306820"},{"issue":"3","key":"e_1_3_2_19_2","first-page":"109","article-title":"Spreading of metastases into cranial tumors: Metastasis of a breast carcinoma to a pilocytic astrocytoma","volume":"18","author":"Muller W","year":"1999","unstructured":"Muller W, Schroder R. Spreading of metastases into cranial tumors: Metastasis of a breast carcinoma to a pilocytic astrocytoma. Clin Neuropathol. 1999;18(3):109-112.","journal-title":"Clin Neuropathol"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022599622949"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12207"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly029"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307701"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.2.256"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/106689690301100214"},{"key":"e_1_3_2_26_2","volume-title":"WHO Classification of Tumors Editorial Board. Central Nervous system tumors","author":"Ellison DW","year":"2021","unstructured":"Ellison DW. WHO Classification of Tumors Editorial Board. Central Nervous system tumors. 5th ed. Lyon(France):International Agency for Research on Cancer; 2021.","edition":"5"},{"key":"e_1_3_2_27_2","volume-title":"Thoracic Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2021","unstructured":"WHO Classification of Tumours Editorial Board. Thoracic Tumours. 5th ed. International Agency for Research on Cancer; 2021.","edition":"5"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241231979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241231979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241231979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:12:18Z","timestamp":1787645538000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241231979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1177\/10668969241231979"],"URL":"https:\/\/doi.org\/10.1177\/10668969241231979","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241231979\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241231979\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241231979\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241231979\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241231979\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241231979\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241231979\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]}}}