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A review of the literature identified a total of 12 reported examples with metastasis to the uterine serosa (1), endometrium (5), cervix (5) and only one with metastasis to the myometrium. This report represents the first case of tumor-to-tumor metastasis involving a clear cell RCC with metastasis to a uterine leiomyoma. The patient was a 50-year-old woman status post-radical nephrectomy for newly diagnosed unilateral clear cell RCC (stage pT3a) with negative margins, who subsequently underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy for the incidental finding of multiple uterine masses measuring up to 14.5\u2005cm suggestive of fibroid on pelvic ultrasound. The pathologic exam of the specimen was consistent with metastatic clear cell RCC (1.2\u2005cm) to uterine leiomyoma, confirmed with keratin, vimentin, CD10, CA9, and PAX8 immunohistochemistry. The patient's postoperative course was uneventful, and no new lesions were identified at follow-up during the past 6 months.<\/jats:p>","DOI":"10.1177\/10668969241231983","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T02:18:56Z","timestamp":1709000336000},"page":"1552-1556","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Metastasis of Clear Cell Renal Cell Carcinoma to Uterine Leiomyoma: First Case Report and Review of Literature"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1333-9744","authenticated-orcid":false,"given":"Sarvenaz","family":"Karamooz","sequence":"first","affiliation":[{"name":"Baylor Scott & White Medical Center \u2013 Temple"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula D.","family":"Binsol","sequence":"additional","affiliation":[{"name":"Baylor Scott & White Medical Center \u2013 Temple"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-4014","authenticated-orcid":false,"given":"Jaya Ruth","family":"Asirvatham","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Texas A&amp;M College of Medicine, Baylor Scott &amp; White Health, Baylor S&amp;W Medical Center West Campus, Temple, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Pargaonkar","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Texas A&amp;M College of Medicine, Baylor Scott &amp; White Medical Center-Pflugerville, Pflugerville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"issue":"3","key":"e_1_3_2_2_2","article-title":"Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment","volume":"39","author":"Bahadoram S","year":"2022","unstructured":"Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L. 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