{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:35:30Z","timestamp":1788291330657,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    Rhabdomyosarcoma is a highly malignant tumor with striated muscle differentiation, which is histologically classified as alveolar, embryonal, pleomorphic, and spindle cell\/sclerosing histological subtype. Rhabdomyosarcoma with\n                    <jats:italic toggle=\"yes\">TFCP2<\/jats:italic>\n                    rearrangement, which usually occurs in the bone, is a newly identified rare spindle and epithelioid rhabdomyosarcoma with characteristic clinicopathological features and molecular alterations. We report a 39-year-old female patient who underwent local excision of the mandibular lesion. Microscopically, the intraosseous tumor was composed of spindle-shaped, epithelioid, and rhabdomyoblastic cells with atypical nuclei and atypical mitotic figures. In addition,\n                    <jats:italic toggle=\"yes\">TFCP2<\/jats:italic>\n                    rearrangement was revealed by the fluorescence in situ hybridization. The tumor was thus correctly diagnosed as rhabdomyosarcoma with\n                    <jats:italic toggle=\"yes\">TFCP2<\/jats:italic>\n                    rearrangement. The patient was scheduled to undergo radiotherapy, and triple-agent chemotherapy after surgery, and no tumor recurrence or metastasis was detected during the 3-month postoperative follow up. Since this tumor is relatively rare and newly recognized, it can be easily misdiagnosed or missed and might be a conundrum of pathological diagnosis. Familiarity with its clinicopathological features and molecular alterations is essential for its correct diagnosis. Therefore, we summarized the clinicopathological, immunohistochemical, and molecular alterations of 43 cases of this rare rhabdomyosarcoma variant in the English-language literature. In addition, the differential diagnosis of this lesion is crucial either.\n                  <\/jats:p>","DOI":"10.1177\/10668969241239676","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T02:42:40Z","timestamp":1710816160000},"page":"125-130","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Rare Case Report of Intraosseous Spindle and Epithelioid Rhabdomyosarcoma With\n                    <i>TFCP2<\/i>\n                    Rearrangement: A Pathological Diagnostic Conundrum and Literature Review"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9799-3145","authenticated-orcid":false,"given":"Cheng","family":"Si","sequence":"first","affiliation":[{"name":"Department of Pathology, Chibi People's Hospital, Hubei University of Science and Technology affiliated Chibi Hospital, Xianning, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chibi People's Hospital, Hubei University of Science and Technology affiliated Chibi Hospital, Xianning, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Administrative Department, Chibi People's Hospital, Hubei University of Science and Technology affiliated Chibi Hospital, Xianning, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01113-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2016.09.011"},{"key":"e_1_3_2_4_2","first-page":"201","volume-title":"World health organization classification of tumors of soft tissue and bone","author":"WHO Classification of Tumors Editorial Board","year":"2020","unstructured":"WHO Classification of Tumors Editorial Board. World health organization classification of tumors of soft tissue and bone. Fifth ed. IARC Press; 2020:201-213."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14323"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5053"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0323-8"},{"issue":"1","key":"e_1_3_2_8_2","first-page":"105876","article-title":"Intraosseous rhabdomyosarcoma of the maxilla with TFCP2 fusion: a rare aggressive subtype with predilection for the gnathic bones","volume":"130","author":"Silva Cunha JL","unstructured":"Silva Cunha JL, Cavalcante IL, da Silva Barros CC, et al. Intraosseous rhabdomyosarcoma of the maxilla with TFCP2 fusion: a rare aggressive subtype with predilection for the gnathic bones. Oral Oncol. 2022 Jul;130(1):105876. doi:https:\/\/doi.org\/10.1016\/j.oraloncology.2022.105876","journal-title":"Oral Oncol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13649"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2018.09.056"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.03.027"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02870-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28185"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01189-1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29935"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01424-x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a006209"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969221140397"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969221137517"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01507-9"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14833"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0540-x"},{"issue":"1","key":"e_1_3_2_23_2","first-page":"954717","article-title":"Update of key clinical, histological and molecular features of malignant bone tumours arising in the craniofacial skeleton","volume":"12","author":"Haefliger S","unstructured":"Haefliger S, Andrei V, Baumhoer D. 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