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Computed tomography of the chest revealed an 8.5 cm hypodense anterior mediastinal mass with peripheral calcifications that raised a wide differential diagnosis including infectious and neoplastic lesions. Following surgical resection, a large cavitary necrotizing and calcified granuloma involving the thymus was identified on histopathological examination. The changes were associated with parasitic eggs that based on their morphology suggested infection due to trematode species. The diagnosis was further corroborated by identification of the increased IgG titers for\n                    <jats:italic toggle=\"yes\">Schistosoma<\/jats:italic>\n                    species (ELISA Kit, NovaTec). The patient's symptoms improved following surgery and praziquantel therapy. This unique presentation emphasizes an unusual manifestation of schistosomiasis that can pose a diagnostic challenge, especially in non-endemic regions. It suggests that mediastinal involvement by schistosomiasis is likely due to an ectopic deposition of the parasitic eggs within a definitive host. Suspicion for schistosomiasis should be heightened based on patient demographics and travel to endemic areas.\n                  <\/jats:p>","DOI":"10.1177\/10668969241241643","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T03:47:52Z","timestamp":1712116072000},"page":"1557-1562","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Large Mediastinal Mass as a Rare Presentation of Schistosomiasis"],"prefix":"10.1177","volume":"32","author":[{"given":"Luke","family":"Bushrow","sequence":"first","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kneuertz","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Maher","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-3130","authenticated-orcid":false,"given":"Konstantin","family":"Shilo","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00221-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X09308020"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-7204-0_19"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1990.11747445"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182466"},{"issue":"3","key":"e_1_3_3_7_2","first-page":"255","article-title":"Paraesophageal varices presenting as a retrocardiac mediastinal mass. 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