{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:15Z","timestamp":1787646495461,"version":"build-2736575974"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>In this study, we describe a patient of primary cutaneous acral CD8-positive lymphoproliferative disorder located in a nonacral region. A 65-year-old male presented with an ill-defined lesion of rubbery consistency and a maximum diameter of 2.5\u2005cm localized in the right thigh. Histologically, it was composed of a diffuse dermal infiltration of medium-sized atypical lymphocytes that expressed CD3, CD8, and TIA-1. In addition, a characteristic paranuclear positivity with CD68 was observed. During the follow-up, the patient had a recurrence of the disease in the abdomen with a lesion showing similar morphology and phenotype. To our knowledge, &lt; 20 patients of primary cutaneous acral CD8-positive lymphoproliferative disorder with a nonacral presentation have been described in English literature. Although rare, its identification is essential to differentiate it from other T-cell lymphoma that express CD8 and cytotoxic markers, and whose clinical courses are very aggressive.<\/jats:p>","DOI":"10.1177\/10668969241248587","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T01:16:53Z","timestamp":1714526213000},"page":"195-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary Cutaneous Acral CD8-Positive Lymphoproliferative Disorder: A Case Report With Nonacral Presentation"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2959-1985","authenticated-orcid":false,"given":"Alejandro","family":"Pasco Pe\u00f1a","sequence":"first","affiliation":[{"name":"Department of Pathology, University Hospital of Navarra, Pamplona, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7625-7895","authenticated-orcid":false,"given":"Luiz Miguel","family":"Nova-Camacho","sequence":"additional","affiliation":[{"name":"Donostia University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Navarra, Pamplona, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Perez","family":"Pelegay","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Reina Sofia Hospital, Tudela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-7378","authenticated-orcid":false,"given":"\u00c1ngel","family":"Panizo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Navarra, Pamplona, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Guerrero-Setas","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Navarra, Pamplona, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Navarra, Pamplona, Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"issue":"2","key":"e_1_3_3_2_2","first-page":"400","article-title":"Primary cutaneous acral CD8+ T-cell lymphoma. Swerdlow SH, Campo E, Pileri SA, et al. The 4th edition of the World Health Organization Classification of tumours of haematopoietic and lymphoid tissues: lymphoid neoplasms","volume":"67","author":"Petrella T","year":"2017","unstructured":"Petrella T, Gaulard P, Berti E, Willemze R, Jaffe EA. Primary cutaneous acral CD8+ T-cell lymphoma. Swerdlow SH, Campo E, Pileri SA, et al. The 4th edition of the World Health Organization Classification of tumours of haematopoietic and lymphoid tissues: lymphoid neoplasms. 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