{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:33:17Z","timestamp":1787646797736,"version":"build-2736575974"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"\n Bronchial papillomas are benign tumors, which can be divided into different subtypes based on the cellular features. So far, no bronchial papilloma with basaloid cell features has been reported. We report a bronchial basaloid papillary tumor in a 67-year-old woman. Tumor recurrence and malignant transformation were observed after a long-term follow-up. The clinical, histological, immunohistochemical, and genetic features were reappraised. The primary tumor was characterized by papillary growth pattern and basaloid neoplastic cells, only a small amount of neoplastic cells showed mature characteristics. The tumor originated from respiratory epithelium and had a low proliferation index by Ki-67. Keratin (KRT) 5\/6 and KRT7 showed patchy or partial positivity. Myoepithelial markers were negative. P63 was diffusely positive, but it was negative in the small amount of tumor cells with mature characteristics. The common genetic alterations (\n EGFR<\/jats:italic>\n ,\n KRAS<\/jats:italic>\n ,\n BRAF<\/jats:italic>\n V600E,\n HER2<\/jats:italic>\n , and\n ALK<\/jats:italic>\n ) of lung cancers were not detected. However, tumor recurrence was observed in the mediastinum and esophagus 12 years after surgery. The recurrent tumor had a morphology overlapping with that of the primary tumor; however, it displayed significantly malignant characteristics. The recurrent tumor was not related to high-risk HPV. A high variant allele frequency was observed in tumor suppressor gene\n BRCA1<\/jats:italic>\n ,\n TP53<\/jats:italic>\n , oncogene\n GNA11<\/jats:italic>\n , and\n KIT<\/jats:italic>\n , which were all missense mutations. Considering the bland features of the primary tumor and the fact of tumor recurrence and undisputed malignant transformation, the basaloid papillary tumor was considered a tumor with uncertain malignant potential.\n <\/jats:p>","DOI":"10.1177\/10668969241256104","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T03:55:27Z","timestamp":1718164527000},"page":"229-235","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Bronchial Basaloid Papillary Tumor of Uncertain Malignant Potential: A Case Report"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-7501","authenticated-orcid":false,"given":"Ling","family":"Nie","sequence":"first","affiliation":[{"name":"Nanjing Drum Tower Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, People's Hospital of Luhe District in Nanjing City, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Guan","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3696-1116","authenticated-orcid":false,"given":"Fanqing","family":"Meng","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Thoracic tumours","author":"WHO Classification of Tumours Editorial Board","year":"2021","unstructured":"WHO Classification of Tumours Editorial Board. Thoracic tumours. 5th ed. Lyon: IARC; 2021.","edition":"5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199811000-00003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.03.030"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.152905"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02659.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182468d06"},{"issue":"5","key":"e_1_3_2_8_2","first-page":"44S","article-title":"An unusual cause of shortness of breath: primary tracheal basal cell adenocarcinoma","volume":"33","author":"Alem\u00e1n Ortiz JR","year":"2016","unstructured":"Alem\u00e1n Ortiz JR, Tasso DM, Fonseca OC, Cintr\u00f3n WR. An unusual cause of shortness of breath: primary tracheal basal cell adenocarcinoma. Fed Pract. 2016;33(Suppl 5):44S\u201047S.","journal-title":"Fed Pract"},{"key":"e_1_3_2_9_2","first-page":"432","article-title":"Basal cell adenoma of the lung identified with obstructive pneumonia","volume":"10","author":"Shima H","year":"2019","unstructured":"Shima H, Yoshida T, Hamada K, Ito A, Ito T. Basal cell adenoma of the lung identified with obstructive pneumonia. Oxf Med Case Reports. 2019;10:432\u2010435.","journal-title":"Oxf Med Case Reports"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2021.03.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840110214"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0458-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.09.009"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2022.05.009"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28840-5"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241256104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241256104","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241256104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:13:43Z","timestamp":1787645623000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241256104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/10668969241256104"],"URL":"https:\/\/doi.org\/10.1177\/10668969241256104","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241256104\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241256104\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241256104\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241256104\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241256104\/v2\/response1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]}}}