{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:27:35Z","timestamp":1787646455498,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    Introduction:\n                    <jats:italic toggle=\"yes\">Sarcina<\/jats:italic>\n                    organisms are rare, gram-positive, sugar-fermenting cocci, identifiable in tissues only by histologic examination or molecular testing. Since its discovery, the pathogenicity and relevance of\n                    <jats:italic toggle=\"yes\">Sarcina<\/jats:italic>\n                    in the human gastrointestinal tract has remained ill-defined. A recent literature review of 66 reported examples demonstrated the potential for severe complications such as emphysematous gastritis and gastric perforation. In pediatrics, colonization is associated with mucosal alterations and\/or gastrointestinal dysmotility\/obstruction with variable outcomes, including death secondary to gastric perforation. Yet, the features of\n                    <jats:italic toggle=\"yes\">Sarcina<\/jats:italic>\n                    colonization within the gastrointestinal tract of adolescents are poorly understood and rarely reported. Methods: We present the gastrointestinal histopathological findings and the complete history of 4 pediatric patients with\n                    <jats:italic toggle=\"yes\">Sarcina<\/jats:italic>\n                    colonization at our institution. Additionally a literature review with focus in the keywords \u201c\n                    <jats:italic toggle=\"yes\">Sarcina<\/jats:italic>\n                    \u201d and \u201cgastrointestinal\u2019 was performed, and the clinical and histopathological features of all previously reported examples of Sarcina in the gastrointestinal tract of pediatric patients were summarized. Results: All 4 patients had delayed gastric emptying, 3 of them due to neurologic disease, and one with pyloric obstruction due to duodenal ulceration with\n                    <jats:italic toggle=\"yes\">Helicobacter<\/jats:italic>\n                    gastritis. In the 3 patients with available esophageal biopsies, it was associated to esophagitis with increased intraepithelial eosinophils. Conclusion: The potential pathogenicity of Sarcina colonization in the gastrointestinal tract of pediatric patients needs to be reevaluated. Due to potential serious complications, the identification of these organisms in the gastrointestinal tract sample should be reported and warrants further evaluation for possible gastrointestinal dysmotility or other mucosal alterations.\n                  <\/jats:p>","DOI":"10.1177\/10668969241260207","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T01:15:11Z","timestamp":1721610911000},"page":"65-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Spectrum of\n                    <i>Sarcina<\/i>\n                    Colonization in the Gastrointestinal Tract of Pediatric and Adolescent Patients"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6723-4299","authenticated-orcid":false,"given":"Yannis","family":"Hadjiyannis","sequence":"first","affiliation":[{"name":"Division of Pediatrics, Department of Pathology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5337-8782","authenticated-orcid":false,"given":"Seemaab","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Pathology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Pathology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Scholz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Waltz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feras","family":"Alissa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary H.","family":"Ayers","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5698-3702","authenticated-orcid":false,"given":"Miguel","family":"Reyes-M\u00fagica","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Pathology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8821-1296","authenticated-orcid":false,"given":"Claudia M.","family":"Salgado","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory, Medicine University of Miami, Miller School of Medicine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0028-RS"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.11.027"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/br.34.1.82-97.1970"},{"issue":"151","key":"e_1_3_2_5_2","first-page":"430","article-title":"History of a case in which a fluid periodically ejected from the stomach contained vegetable organisms of an undescribed form","volume":"57","author":"Goodsir J","year":"1842","unstructured":"Goodsir J, Wilson G. History of a case in which a fluid periodically ejected from the stomach contained vegetable organisms of an undescribed form. Edinb Med Surg J. 1842;57(151):430\u2010443.","journal-title":"Edinb Med Surg J"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.07.025"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000518305"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/CDFF04HE9FHDQPAN"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.02.021"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822911e6"},{"issue":"10","key":"e_1_3_2_11_2","first-page":"103","article-title":"Co-existence of Sarcina organisms and Helicobacter pylori gastritis\/duodenitis in pediatric siblings","volume":"1","author":"Sauter JL","year":"2013","unstructured":"Sauter JL, Nayar SK, Anders PD, et al. Co-existence of Sarcina organisms and Helicobacter pylori gastritis\/duodenitis in pediatric siblings. J Clin Anat Pathol (JCAP). 2013;1(10):103-108.","journal-title":"J Clin Anat Pathol (JCAP)"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omu046"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13406"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00145"},{"key":"e_1_3_2_15_2","first-page":"766","article-title":"Duodenitis caused by Sarcina ventriculi in a case with Celiac disease and selective IgA deficiency","volume":"42","author":"Canan O","year":"2017","unstructured":"Canan O, \u00d6zkale M, Kayasel\u00e7uk F. Duodenitis caused by Sarcina ventriculi in a case with Celiac disease and selective IgA deficiency. Cukurova Med J. 2017;42:766\u2010768.","journal-title":"Cukurova Med J"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2014.8028"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002339"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896919873715"},{"issue":"1","key":"e_1_3_2_19_2","first-page":"134","article-title":"Clostridium ventriculi infection in a child with phenylketonuria","volume":"50","author":"Sergi C","year":"2020","unstructured":"Sergi C, Lam J, Persad R. Clostridium ventriculi infection in a child with phenylketonuria. Ann Clin Lab Sci. 2020;50(1):134\u2010135.","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_3_2_20_2","article-title":"Sarcina ventriculi a rare pathogen","volume":"11","author":"Marcelino LP","unstructured":"Marcelino LP, Valentini DF, Machado SMDS, Schaefer PG, Rivero RC, Osvaldt AB. Sarcina ventriculi a rare pathogen. Autops Case Rep. 2021 Oct 18;11:e2021337.","journal-title":"Autops Case Rep"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.163.13.391"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21012-x"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241260207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241260207","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241260207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:13:19Z","timestamp":1787645599000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241260207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,21]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/10668969241260207"],"URL":"https:\/\/doi.org\/10.1177\/10668969241260207","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,21]]}}}