{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:29:11Z","timestamp":1787646551986,"version":"build-2736575974"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    High-grade appendiceal mucinous neoplasm (HAMN) has been separated from appendiceal adenocarcinoma recently as an independent entity and categorized into appendiceal mucinous neoplasms. These neoplasms demonstrate distinct histological characteristics, including architectures and appendiceal mural changes similar to low-grade appendiceal mucinous neoplasm but with high-grade cytology, and no infiltrative invasion. Overt mucinous feature are not evident in some cases as the high-grade neoplastic epithelium may show intracytoplasmic mucin reduction. Occasionally, the neoplastic epithelial cells show florid proliferation and tubulovillous configuration and may be misdiagnosed as appendiceal tubulovillous adenoma. We report the case of a 67-year-old woman with appendicular dilatation and luminal mucin. She underwent an ileocecoectomy. The appendiceal lesion was found histologically to be a HAMN, which closely resembled appendiceal tubulovillous adenoma. The tumor cells demonstrated wild-type p53 expression and mismatch repair proficiency by immunochemistry. Molecular testing showed 1\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    mutation, 2\n                    <jats:italic toggle=\"yes\">PIK3CA<\/jats:italic>\n                    mutations, and 1\n                    <jats:italic toggle=\"yes\">BRCA2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">EP300<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">TGFBR2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CHD4<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CREBBP<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">FANCC<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">PKHD1<\/jats:italic>\n                    mutation each in the tumor. The patient was followed up for 1 year with no evidence of disease.\n                  <\/jats:p>","DOI":"10.1177\/10668969241260232","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T07:22:16Z","timestamp":1721892136000},"page":"450-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["High-Grade Appendiceal Mucinous Neoplasm Mimicking Appendiceal Tubulovillous Adenoma: A Case Report and Literature Review"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-4558","authenticated-orcid":false,"given":"Huilin","family":"Shao","sequence":"first","affiliation":[{"name":"Capital Medical University Affiliated Beijing Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-4002","authenticated-orcid":false,"given":"Shuhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Capital Medical University Affiliated Beijing Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0497-8247","authenticated-orcid":false,"given":"Weihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Capital Medical University Affiliated Beijing Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Capital Medical University Affiliated Beijing Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000535"},{"key":"e_1_3_2_3_2","first-page":"144","volume-title":"WHO Classification of Tumours: Digestive System Tumours","author":"Misdraji J","year":"2019","unstructured":"Misdraji J, Carr N, Pai R. Appendiceal mucinous neoplasm. In: WHO Classification of Tumours Editorial Broad, ed. WHO Classification of Tumours: Digestive System Tumours. 5th ed. International Agency for Research on Cancer; 2019:144\u2013146.","edition":"5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200308000-00006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181af6067"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0430-OA"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13324"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13986"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03589-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13924"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02906-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.47"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241260232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241260232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241260232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:14:38Z","timestamp":1787645678000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241260232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/10668969241260232"],"URL":"https:\/\/doi.org\/10.1177\/10668969241260232","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241260232\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241260232\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241260232\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241260232\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241260232\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]}}}