{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:48:42Z","timestamp":1787683722180,"version":"build-2784847793"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background.<\/jats:italic>\n                    Neuroendocrine lesions arising from mediastinal teratomas are rare tumors with only small number of patients reported in literature. The behavior of these lesions appears to be different from traditional neuroendocrine neoplasms. A comprehensive review will be valuable for histologic assessment and treatment planning for similar cases.\n                    <jats:italic toggle=\"yes\">Case presentation.<\/jats:italic>\n                    We present an example of a 57-year-old man who presented with cough. Subsequent work-up revealed an anterior mediastinal mass of 2.1 cm on computed tomography. The patient underwent robot-assisted thoracoscopic thymectomy. Histological examination revealed a mature cystic teratoma with a neuroendocrine component consisting of clusters of tumor cells with round to oval nuclei and a \u201csalt-and-pepper\u201d chromatin pattern. The tumor cells were immunoreactive to cytokeratin, synaptophysin, chromogranin, and INSM1, with a Ki-67 proliferative index of 4%. A histological diagnosis was mature teratoma with well-differentiated low-grade neuroendocrine tumor (carcinoid) was made. The patient was well and without disease after complete surgical excision at 10 months.\n                    <jats:italic toggle=\"yes\">Literature review.<\/jats:italic>\n                    Literature reviewed yielded 13 examples of neuroendocrine lesions arising from mediastinal teratomas. No disease-related mortality was reported, even in lesions with high-grade neuroendocrine, carcinomatous, or immature teratomatous components.\n                    <jats:italic toggle=\"yes\">Conclusions.<\/jats:italic>\n                    Surgical removal is the mainstay of treatment of these lesions, and the presence of a neuroendocrine component does not appear to negatively affect prognosis.\n                  <\/jats:p>","DOI":"10.1177\/10668969241261552","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T21:31:00Z","timestamp":1721597460000},"page":"466-471","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Neuroendocrine Lesions Arising From Mediastinal Teratoma\u2014A Case Report and Literature Review"],"prefix":"10.1177","volume":"33","author":[{"given":"Pensi P. 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