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Herein, we report 3 patients with POT and the clinicopathological features of POT previously reported in the literature. A 12-year-old, 19-year-old, and 4-year-old patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible. Imaging exams revealed radiolucent lesions associated with unerupted teeth. The lesions were surgically removed, and the histopathological examination revealed spindle-to-ovoid mesenchymal cells in a fibromyxoid stroma surfaced by columnar odontogenic epithelial cells with reverse nuclear polarization. Deposition of mineralized tissue was observed. The final diagnosis was POT, and patients did not exhibit signs of recurrence. POT should be included in the differential diagnoses of intraosseous lesions in the posterior mandible in pediatric patients.<\/jats:p>","DOI":"10.1177\/10668969241266925","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T15:19:48Z","timestamp":1722957588000},"page":"546-556","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Primordial Odontogenic Tumor: A Review of the Literature and Report of Three New Patients"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-4106","authenticated-orcid":false,"given":"Israel Leal","family":"Cavalcante","sequence":"first","affiliation":[{"name":"University of Fortaleza"},{"name":"Department of Oral Diagnosis and Pathology, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio C\u00e9sar da Silva","family":"Barros","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Postgraduate Program in Dental Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit\u00f3ria Maria","family":"Sousa Cruz","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Bispo","family":"Costa","sequence":"additional","affiliation":[{"name":"Traumatology and Bucomaxillofacial Surgery, General Hospital of Fortaleza, Fortaleza, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Fac\u00f3","family":"da Silveira Santos","sequence":"additional","affiliation":[{"name":"Traumatology and Bucomaxillofacial Surgery, General Hospital of Fortaleza, Fortaleza, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"de Le\u00f3n-Garza","sequence":"additional","affiliation":[{"name":"Hospital Issste Puebla, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Parra-Salazar","sequence":"additional","affiliation":[{"name":"Hospital Issste Puebla, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Onner","family":"Cruz-Tapia","sequence":"additional","affiliation":[{"name":"National Autonomous University of Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Service, General Hospital of the West, Dr Jos\u00e9 Gregorio Hern\u00e1ndez, Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Manresa","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Service, General Hospital of the West, Dr Jos\u00e9 Gregorio Hern\u00e1ndez, Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Service, General Hospital of the West, Dr Jos\u00e9 Gregorio Hern\u00e1ndez, Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Villarroel-Dorrego","sequence":"additional","affiliation":[{"name":"Universidad Central de Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Turatti","sequence":"additional","affiliation":[{"name":"University of Fortaleza"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Barroso","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"University of Fortaleza"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Augusto Benevenuto","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis and Pathology, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12451"},{"key":"e_1_3_2_3_2","article-title":"Primordial odontogenic tumor: a systematic review","volume":"25","author":"Bologna-Molina R","year":"2020","unstructured":"Bologna-Molina R, Pereira-Prado V, S\u00e1nchez-Romero C, Gonz\u00e1lez-Gonz\u00e1lez R, Mosqueda-Taylor A. 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