{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:29:07Z","timestamp":1787646547361,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    In the diagnostic workup of poorly differentiated tumors, T-cell receptor (TCR) clonality has long been considered as evidence of T-cell lymphoma.\n                    <jats:italic toggle=\"yes\">MET<\/jats:italic>\n                    exon 14 skipping (\n                    <jats:italic toggle=\"yes\">METex14<\/jats:italic>\n                    ) is a mutation typically seen in lung adenocarcinoma. Herein, we present the first report of\n                    <jats:italic toggle=\"yes\">METex14<\/jats:italic>\n                    lung adenocarcinoma with isolated monoclonal TCR\u03b3 gene rearrangement. A 69-year-old woman presented to an outside hospital with pleural effusions. A pleural decortication demonstrated malignant cells positive for CD30 and CD138 but negative for BerEP4, KRT5, and EMA. An equivocal HHV8 staining was interpreted as positive, leading to the erroneous outside diagnosis of primary effusion lymphoma. Additional workup at our institution revealed a lack of HHV8 and T-cell markers but the presence of TCR\u03b3 clonality, pankeratin, and TTF1 expression. Repeat TCR\u03b3 testing on the in-house biopsy was negative for clonality. Next-generation sequencing detected\n                    <jats:italic toggle=\"yes\">METex14<\/jats:italic>\n                    , confirming the diagnosis of lung adenocarcinoma. The potential diagnostic pitfall and prognostic\/predictive implications are discussed.\n                  <\/jats:p>","DOI":"10.1177\/10668969241266927","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T02:33:45Z","timestamp":1724034825000},"page":"484-489","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated Monoclonal T-Cell Receptor Gene Rearrangement in a Lung Adenocarcinoma Harboring\n                    <i>MET<\/i>\n                    Exon 14 Skipping: Diagnostic Pitfall"],"prefix":"10.1177","volume":"33","author":[{"given":"Wangpan Jackson","family":"Shi","sequence":"first","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Nguyen","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-You","family":"Wang","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwole","family":"Fadare","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-3094","authenticated-orcid":false,"given":"Li","family":"Lei","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14032"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-692616"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896920946835"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.0674"},{"issue":"21","key":"e_1_3_2_7_2","first-page":"5913","article-title":"The T-cell receptor V beta gene usage in tumor-infiltrating lymphocytes and blood of patients with hepatocellular carcinoma","volume":"52","author":"Weidmann E","year":"1992","unstructured":"Weidmann E, Whiteside TL, Giorda R, et al. The T-cell receptor V beta gene usage in tumor-infiltrating lymphocytes and blood of patients with hepatocellular carcinoma. Cancer Res. 1992;52(21):5913\u20105920.","journal-title":"Cancer Res"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116278"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3581"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-022-03330-1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118790"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0256"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0592-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64924-3"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31760"},{"issue":"7","key":"e_1_3_2_16_2","article-title":"Tracking T cell clonal dynamics across time and space in metastatic colorectal cancer","volume":"83","author":"Baker AM","year":"2023","unstructured":"Baker AM, Berner A, Ronel T, et al. Tracking T cell clonal dynamics across time and space in metastatic colorectal cancer. Cancer Res. 2023;83(7_Suppl):Abstract nr 5934. 2023. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR.","journal-title":"Cancer Res"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02566-0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.152631"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24343-x"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241266927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241266927","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241266927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:14:16Z","timestamp":1787645656000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241266927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,18]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/10668969241266927"],"URL":"https:\/\/doi.org\/10.1177\/10668969241266927","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241266927\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241266927\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241266927\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241266927\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241266927\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241266927\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241266927\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241266927\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,18]]}}}