{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:22Z","timestamp":1787646502540,"version":"build-2736575974"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aim.<\/jats:italic>\n                    The study aims to explore the expression levels and clinicopathological significance of BRAF V600E and mucin 6 in intrahepatic cholangiocarcinoma.\n                    <jats:italic toggle=\"yes\">Method.<\/jats:italic>\n                    Immunohistochemistry for BRAF V600E and mucin 6 was performed in 110 patients with intrahepatic cholangiocarcinoma. Subsequently, a comprehensive review of medical records and clinicopathological analysis was undertaken.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    BRAF V600E expression was detected in 11 patients (10%); mucin 6 expression was observed in 19 intrahepatic cholangiocarcinoma specimens (17%). Thereafter, Cox regression models indicated that positive expression of either MUC6 positive (hazard ratio\u2009=\u20090.091, 95% confidence interval\u2009=\u20090.034-0.247,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001) and BRAF V600E positive (hazard ratio =0.150, 95% confidence interval\u2009=\u20090.058-0.388,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001) was significantly linked with longer overall survival for intrahepatic cholangiocarcinoma patients.\n                    <jats:italic toggle=\"yes\">Conclusion.<\/jats:italic>\n                    The study concludes that positive expression of BRAF V600E and mucin 6 could potentially implied significant survival benefits for patients diagnosed with intrahepatic cholangiocarcinoma.\n                  <\/jats:p>","DOI":"10.1177\/10668969241266930","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T02:55:24Z","timestamp":1725850524000},"page":"399-407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Expression and Clinicopathological Significance of BRAF V600E and Mucin 6 in Intrahepatic Cholangiocarcinoma: A Retrospective Study"],"prefix":"10.1177","volume":"33","author":[{"given":"Shurui","family":"Wu","sequence":"first","affiliation":[{"name":"Chinese PLA General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Hospital of PLA 80th Group Army, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Qianjiang River Hospital for Nationalities, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Tang","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3876-4805","authenticated-orcid":false,"given":"Zhanbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318195e164"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(97)00088-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16143"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.11.030"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-2-10"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2006.01350.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.01.021"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004621"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6519"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4937"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/24563774"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25625"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9250757"},{"issue":"19","key":"e_1_3_2_16_2","first-page":"1472","article-title":"Analysis of clinicopathological characteristics of papillary thyroid carcinoma and BRAF V600E gene mutation","volume":"32","author":"Zhao Y","year":"2018","unstructured":"Zhao Y, Wang HY, Wang CB, et al. 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