{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:22Z","timestamp":1787646502573,"version":"build-2736575974"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"\n Background<\/jats:title>\n Urothelial carcinoma with trophoblastic differentiation is a rare type of urothelial carcinoma that poses a diagnostic challenge.<\/jats:p>\n <\/jats:sec>\n \n Case details<\/jats:title>\n A 50-year-old man presented with hematuria for 4 months duration. Ultrasonography examination showed polypoidal lesions along the right lateral wall and near the right vesicoureteric junction of the urinary bladder. The transurethral resection of the bladder tumor (TURBT) specimen showed marked necrosis and urothelial tumor cells arranged in nests, sheets, and papillae, admixed with multinucleated large cells. Deep muscle and extensive lymphovascular invasion were noted. The tumor cells were diffuse immunopositive for GATA3 and focal positive for p63 and SALL4. Large multinucleated tumor cells were immunopositive for \u03b2-hCG, GATA3, inhibin-\u03b1, and PLAP, focally positive for SALL4 while negative for p63. The patient denied further treatment and succumbed to the disease after 8 months of the TURBT procedure.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n We report a rare invasive urothelial carcinoma with trophoblastic differentiation and discuss the differential diagnosis and literature review.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10668969241266934","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T02:56:51Z","timestamp":1724122611000},"page":"490-494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Urothelial Carcinoma with Trophoblastic Differentiation\u2014A Report with Review"],"prefix":"10.1177","volume":"33","author":[{"given":"Monica","family":"Mishra","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-6835","authenticated-orcid":false,"given":"Pavithra","family":"Ayyanar","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar Ranjan","family":"Tripathy","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Das","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS), Bhubaneswar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"81","volume-title":"WHO Classification of tumours of the urinary system and male genital organs","author":"Grignon DJ","year":"2022","unstructured":"Grignon DJ, Al-Ahmadie H, Algaba F, Amin MB, Comperat E, Dyrskjot L. Urothelial tumors infiltrating urothelial carcinoma. In: Moch H, (editor). WHO Classification of tumours of the urinary system and male genital organs, 5th ed. 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