{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:26Z","timestamp":1787646506914,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Lymphoepithelioma-like intrahepatic cholangiocarcinoma (LEL-ICC) is a rare liver tumor that appears as a hepatic nodule on imaging with a specific pathological pattern, and the definitive diagnosis relies on its pathological histomorphology, immunophenotype, and Epstein-Barr encoding region test. Radical surgical resection is the primary treatment modality, and immunotherapy is expected to be a new adjuvant treatment option. LEL-ICC with massive multinucleated giant cell infiltration has not been reported so far. In this article, we report a patient with LEL-ICC showing massive multinucleated giant cell infiltration, review the relevant literature, and analyze its clinicopathological features and prognosis to accumulate experience for the accurate diagnosis of LEL-ICC.<\/jats:p>","DOI":"10.1177\/10668969241268392","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T04:40:36Z","timestamp":1724992836000},"page":"706-710","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Lymphoepithelioma-Like Intrahepatic Cholangiocarcinoma With Massive Multinucleated Giant Cell Reaction"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6248-5559","authenticated-orcid":false,"given":"Fang","family":"Luyao","sequence":"first","affiliation":[{"name":"Department of Graduate School, Hebei North University, Zhangjiakou, Hebei, China"},{"name":"Deparment of Pathology, Hebei General Hospital, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Xiangnan","sequence":"additional","affiliation":[{"name":"Deparment of Pathology, Hebei General Hospital, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Qiaoyun","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Hebei North University, Zhangjiakou, Hebei, China"},{"name":"Deparment of Pathology, Hebei General Hospital, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Huanping","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Hebei North University, Zhangjiakou, Hebei, China"},{"name":"Deparment of Pathology, Hebei General Hospital, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Tianwen","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Hebei North University, Zhangjiakou, Hebei, China"},{"name":"Deparment of Pathology, Hebei General Hospital, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2657-2487","authenticated-orcid":false,"given":"Zhao","family":"Huanfen","sequence":"additional","affiliation":[{"name":"Deparment of Pathology, Hebei General Hospital, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00012"},{"issue":"5","key":"e_1_3_2_3_2","first-page":"600","article-title":"A case of EBV-positive intrahepatic cholangiocarcinoma of the bile ducts with lymphoepithelioma-like cholangiocarcinoma","volume":"40","author":"Lei QC","year":"2022","unstructured":"Lei QC, Zhang YH, Zheng HZ, Wang FJ, Zhen ZJ, Chen HW. A case of EBV-positive intrahepatic cholangiocarcinoma of the bile ducts with lymphoepithelioma-like cholangiocarcinoma. J Guangdong Med Univ. 2022;40(5):600-602. doi:https:\/\/doi.org\/10.3969\/j.issn.1005-4057.2022.05.030","journal-title":"J Guangdong Med Univ"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.08.105"},{"issue":"4","key":"e_1_3_2_5_2","first-page":"260","article-title":"Clinicopathologic features of EBV-associated lymphoepithelioma-like intrahepatic cholangiocellular carcinoma","volume":"28","author":"Tan CH","year":"2021","unstructured":"Tan CH, Weng JL, Zeng ZQ, et al. Clinicopathologic features of EBV-associated lymphoepithelioma-like intrahepatic cholangiocellular carcinoma. Chin J Diagn Pathol. 2021;28(4):260-263. doi:https:\/\/doi.org\/10.3969\/j.issn.1007-8096.2021.04.005","journal-title":"Chin J Diagn Pathol"},{"issue":"17","key":"e_1_3_2_6_2","first-page":"871","article-title":"Clinicopathologic analysis of intrahepatic lymphoepithelioma-like cholangiocellular carcinoma","volume":"47","author":"Liu ZJ","year":"2020","unstructured":"Liu ZJ, Zhang YJ, Yin P, Liao HF. Clinicopathologic analysis of intrahepatic lymphoepithelioma-like cholangiocellular carcinoma. China Cancer Clin. 2020;47(17):871-875. doi:https:\/\/doi.org\/10.3969\/j.issn.1000-8179.2020.17.869","journal-title":"China Cancer Clin"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12455"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.10.037"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14580"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i27.4252"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.01.031"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0820-y"},{"issue":"5","key":"e_1_3_2_13_2","first-page":"466","article-title":"Study on the correlation between ARID1A expression and immune cell infiltration and prognosis of intrahepatic cholangiocarcinoma","volume":"28","author":"Zhang ZW","year":"2022","unstructured":"Zhang ZW, Zhang W. Study on the correlation between ARID1A expression and immune cell infiltration and prognosis of intrahepatic cholangiocarcinoma. J Tianjin Med Univ. 2022;28(5):466-471.","journal-title":"J Tianjin Med Univ"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11949"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15339"},{"issue":"02","key":"e_1_3_2_16_2","first-page":"469","article-title":"Role of tumor-associated macrophages in cholangiocarcinoma","volume":"39","author":"Han PS","year":"2023","unstructured":"Han PS, Yang L, Cui T, et al. Role of tumor-associated macrophages in cholangiocarcinoma. J Clin Hepatobiliary Dis. 2023;39(02):469-473.","journal-title":"J Clin Hepatobiliary Dis"},{"issue":"11","key":"e_1_3_2_17_2","first-page":"1189","article-title":"Study on the value of the eighth edition of AJCC staging system in evaluating the prognosis of patients with intrahepatic cholangiocarcinoma radical resection","volume":"39","author":"Yang FC","year":"2019","unstructured":"Yang FC, Bou ZY, Li M, et al. Study on the value of the eighth edition of AJCC staging system in evaluating the prognosis of patients with intrahepatic cholangiocarcinoma radical resection. Chin J Pract Surg. 2019;39(11):1189-1194. doi:https:\/\/doi.org\/10.19538\/j.cjps.issn1005-2208.2019.11.17","journal-title":"Chin J Pract Surg"},{"issue":"12","key":"e_1_3_2_18_2","first-page":"1044","article-title":"Clinicopathologic analysis of lymphoepithelioma-like intrahepatic cholangiocarcinoma","volume":"28","author":"Shen SY","year":"2021","unstructured":"Shen SY, Jiang J, Zhang JC, Wu T, Wang HF, Wu JH. Clinicopathologic analysis of lymphoepithelioma-like intrahepatic cholangiocarcinoma. Chin J Diagn Pathol. 2021;28(12):1044-1047. doi:https:\/\/doi.org\/10.3969\/j.issn.1007-8096.2021.12.012","journal-title":"Chin J Diagn Pathol"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241268392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241268392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241268392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:15:55Z","timestamp":1787645755000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241268392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/10668969241268392"],"URL":"https:\/\/doi.org\/10.1177\/10668969241268392","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241268392\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241268392\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241268392\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241268392\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241268392\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241268392\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241268392\/v1\/review2","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]}}}