{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:24Z","timestamp":1787646504963,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Cholangiocarcinoma\u2014with a growing incidence rate and poor prognosis\u2014is not an uncommon cancer. Molecular profiling can reveal actionable aberrations in at least a third of the tumors. This is especially so in the case of intrahepatic cholangiocarcinoma (ICC), where mutations in the isocitrate dehydrogenase 1 and 2 genes (\n                      <jats:italic toggle=\"yes\">IDH1\/2<\/jats:italic>\n                      ) make up 15%\u201320% of these tumors.\n                      <jats:italic toggle=\"yes\">IDH1\/2<\/jats:italic>\n                      mutant ICC is a rare disease that has not been adequately reported. To expand the spectrum of findings seen in these patients, we present a single institution case series.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We descriptively characterize the clinical, radiological, and histopathological findings of 12 such patients.\n                      <jats:italic toggle=\"yes\">IDH1\/2<\/jats:italic>\n                      mutant ICC was found in elderly women, with two-thirds of patients having additional co-mutations. Anecdotally, patients who did receive systemic and\/or locoregional therapies had long-term durable outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings indicate an increasing need to personalize an approach for these patients with specific molecular alterations. With the advent of the\n                      <jats:italic toggle=\"yes\">IDH1<\/jats:italic>\n                      inhibitor ivosidenib and other inhibitors in this space,\n                      <jats:italic toggle=\"yes\">IDH1\/2<\/jats:italic>\n                      mutation have both prognostic and predictive value. Our series builds upon the patterns and findings seen in these patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969241271397","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T11:19:03Z","timestamp":1727176743000},"page":"417-425","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spectrum of Findings Seen in Patients With\n                    <i>IDH1\/2-Mutant<\/i>\n                    Cholangiocarcinoma"],"prefix":"10.1177","volume":"33","author":[{"given":"Andrea Siobhan","family":"Kierans","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-9324","authenticated-orcid":false,"given":"Areeb","family":"Lutfi","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaz Khan","family":"Afghan","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahrish","family":"Khan","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Javaid","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Michael","family":"Currie","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rocca","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Samstein","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encouse","family":"Golden","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeta","family":"Popa","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4685-1727","authenticated-orcid":false,"given":"Erika","family":"Hissong","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pashtoon Murtaza","family":"Kasi","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0078"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.157"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3375"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113310"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.05.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.444"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S70716"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2981"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08617"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0386"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2019.03.10"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0210"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00300-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2020-0045"},{"key":"e_1_3_3_17_2","unstructured":"SEER [Internet]. 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