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In radiology studies, the mammogram showed increased density\/attenuation, and the ultrasound revealed a change in the overall echogenicity with hyperechoic and anechoic areas. The stromal compartment contained smooth muscle bundles and adipose tissue on microscopic examination. The stromal cells showed\n                    <jats:italic toggle=\"yes\">HMGA2<\/jats:italic>\n                    gene rearrangement by fluorescence in-situ hybridization analysis and overexpression of HMGA2 by immunohistochemistry. The breast myoid hamartoma is likely underpinned by\n                    <jats:italic toggle=\"yes\">HMGA2<\/jats:italic>\n                    gene rearrangement and HMGA2 protein overexpression, which can be used as an ancillary test to diagnose this rare breast lesion. Although most myoid hamartomas have a benign clinical course, the likelihood of malignant transformation should always be considered.\n                  <\/jats:p>","DOI":"10.1177\/10668969241271420","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T20:31:37Z","timestamp":1730233897000},"page":"689-699","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Myoid Hamartoma of the Breast With\n                    <i>HMGA2<\/i>\n                    Rearrangement and Associated In-Situ and Invasive Carcinoma: Case Report and Review of Literature"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-4690","authenticated-orcid":false,"given":"Flora Mae G.","family":"Sta. Ines","sequence":"first","affiliation":[{"name":"Women & Infants Hospital of Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivali","family":"Marketkar","sequence":"additional","affiliation":[{"name":"Women & Infants Hospital of Rhode Island"},{"name":"Department of Pathology, The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Warren Alpert Medical School of Brown University, Providence, RI, USA"},{"name":"Women & Infants Hospital of Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmini","family":"Manrai","sequence":"additional","affiliation":[{"name":"Women & Infants Hospital of Rhode Island"},{"name":"Department of Pathology, The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"James Sung","sequence":"additional","affiliation":[{"name":"Women & Infants Hospital of Rhode Island"},{"name":"Department of Pathology, The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Bridge","sequence":"additional","affiliation":[{"name":"Cytogenetics and FISH, ProPath, Dallas"},{"name":"University of Nebraska Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-5703","authenticated-orcid":false,"given":"Kamaljeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Women & Infants Hospital of Rhode Island"},{"name":"Department of Pathology, The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Breast tumors","author":"WHO Classification of Tumours Editorial Board","year":"2019","unstructured":"WHO Classification of Tumours Editorial Board. 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