{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:33:33Z","timestamp":1787646813817,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Extra-skeletal osteosarcoma is a rare form of malignant soft tissue sarcoma. Its occurrence in the prostate gland is particularly uncommon. In this case report, we present a patient diagnosed with osteosarcoma arising within the prostatic gland. A 58-year-old man was initially diagnosed with Gleason 8 prostate acinar adenocarcinoma following a transurethral resection (TUR) of the prostate. This diagnosis was accompanied by locoregional involvement and multiple bone metastases. The patient underwent a treatment regimen including complete androgen blockade, chemotherapy, greenlight laser prostate vaporization, and palliative radiotherapy. After treatment, he achieved a complete biochemical response, and his bone metastases remained stable. However, at 16 months post-diagnosis, clinical follow-up by means of radiological examinations revealed an increase in the size of the prostatic lesion, along with additional infiltration of the tumor into the rectum and bladder walls. Remarkably, a mesenchymal tumor proliferation with intratumor calcifications was observed. A subsequent TUR biopsy of the prostate showed a malignant tumor spindle and ovoid cell proliferation with high-grade nuclear atypia, necrosis, and islets of osteoid formation, leading to a final diagnosis of high-grade prostatic extra-skeletal osteosarcoma. Despite undergoing chemotherapy, the patient's condition progressed with the development of pulmonary and liver metastases, culminating in his demise.<\/jats:p>","DOI":"10.1177\/10668969241283735","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T04:07:12Z","timestamp":1727755632000},"page":"772-777","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Extra-Skeletal Osteosarcoma of the Prostate After Treated Prostatic Acinar Adenocarcinoma: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8624-2427","authenticated-orcid":false,"given":"Carmen Rodr\u00edguez","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Ramos","family":"Soler","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe"},{"name":"Pathology Department, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n Torregrosa","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier P\u00e9rez","family":"Ardav\u00edn","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Rubio Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Giner","family":"Segura","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe"},{"name":"Pathology Department, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.01.034"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31817b6061"},{"key":"e_1_3_2_4_2","volume-title":"Urinary and male genital tumours","author":"WHO Classification of Tumours","year":"2022","unstructured":"WHO Classification of Tumours. 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