{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:30:12Z","timestamp":1787646612697,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Autosomal dominant polycystic kidney disease (ADPKD) may be associated with various epithelial malignancies. The most reported ones are papillary renal cell carcinoma (RCC) and clear cell RCC. Only one noninvasive urothelial carcinoma arising in the renal pelvis has been previously reported in the setting of ADPKD in the English literature. A 52-year-old patient with ADPKD and a history of renal transplant presented with a poorly differentiated sarcomatoid neoplasm in his native left polycystic kidney. A recognizable urothelial or renal cell carcinoma differentiation was not identified in the resected neoplasm microscopically. The initial diagnosis for this specimen was challenging on morphology and immunohistochemistry, but targeted next-generation sequencing provided molecular evidence in support of urothelial origin, indicating a hotspot mutation \u2212124 C\u2009&gt;\u2009T in the\n                    <jats:italic toggle=\"yes\">TERT<\/jats:italic>\n                    promoter (C228 T) and loss of heterozygosity on chromosomes 9p and 8p. This tumor is unique because, to our knowledge, this is the first report of upper tract sarcomatoid urothelial carcinoma in a patient with ADPKD.\n                  <\/jats:p>","DOI":"10.1177\/10668969241286055","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T03:23:28Z","timestamp":1728444208000},"page":"783-790","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sarcomatoid Urothelial Carcinoma Arising in Autosomal Dominant Polycystic Kidney Disease: A Case Report and Literature Review"],"prefix":"10.1177","volume":"33","author":[{"given":"Yousef","family":"Bolous","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-8846","authenticated-orcid":false,"given":"Kiril","family":"Trpkov","sequence":"additional","affiliation":[{"name":"Rockyview General Hospital, Alberta Precision Labs, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-4806","authenticated-orcid":false,"given":"Farshid","family":"Siadat","sequence":"additional","affiliation":[{"name":"Rockyview General Hospital, Alberta Precision Labs, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soufiane","family":"El Hallani","sequence":"additional","affiliation":[{"name":"Alberta Precision Labs Walter C. Mackenzie Health Sciences Centre, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-6254","authenticated-orcid":false,"given":"Jennifer","family":"Merrimen","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9843-5373","authenticated-orcid":false,"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, Dalhousie University, Halifax, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30250-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.02.078"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000351049"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896920942891"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4236\/ojrad.2012.23012"},{"issue":"11","key":"e_1_3_2_7_2","first-page":"1359","article-title":"Rhabdomyosarcoma associated with polycystic kidney: a case report with light and electron microscopic observation","volume":"23","author":"Hayakawa M","year":"1981","unstructured":"Hayakawa M, Kinoshita H, Jitsukawa S, Ishikawa H, Mukai M, Tazaki H. 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