{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:22Z","timestamp":1787646502366,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The significance of radiation therapy in cancer treatment comes with associated complications, including fibrosis, osteonecrosis, and the development of secondary malignancies, such as malignant peripheral nerve sheath tumors (MPNSTs). We emphasize the importance of understanding these complications for an effective patient management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a 47-year-old man with a history of squamous cell carcinoma of the tongue, treated with surgery, chemotherapy, and radiation therapy. The patient later presented with symptoms that led to the discovery of an intraosseous MPNST.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histopathological examination revealed characteristic features of MPNST, including spindle cells arranged is sweeping fascicles with contrasting hypercellular and hypocellular areas, producing a marble-like pattern, with atypical wavy, buckled, hyperchromatic nuclei, and brisk mitotic activity. Immunohistochemical analysis showed patchy positive staining for S100 and SOX10, and a complete loss of H3K27me3 expression. This report underscores the challenge of diagnosing secondary malignancies post-radiation therapy and the importance of careful histological examination to differentiate them from other conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, radiation-induced secondary malignancies are a significant late side effect of radiation therapy that can profoundly impact treatment decision-making and requires a high index of suspicion during post radiation surveillance. Malignant peripheral nerve sheath tumor serves as a pertinent example, highlighting the importance of considering long-term risks when developing optimal management plans for cancer patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969241286061","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T04:26:40Z","timestamp":1728275200000},"page":"916-920","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Radiation-Induced Intraosseous Malignant Peripheral Nerve Sheath Tumor: A Case Report"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-6845","authenticated-orcid":false,"given":"Celeste E.","family":"Wagner","sequence":"first","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Alfattal","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetic Pathology, MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-957X","authenticated-orcid":false,"given":"Jayati","family":"Mallick","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"issue":"6","key":"e_1_3_2_2_2","first-page":"2597","article-title":"Incidence and survival in sarcoma in the United Sates: a focus on musculoskeletal lesions","volume":"33","author":"Ng VY","year":"2013","unstructured":"Ng VY, Scharschmidt TJ, Mayerson JL, Fisher JL. Incidence and survival in sarcoma in the United Sates: a focus on musculoskeletal lesions. Anticancer Res. 2013;33(6):2597-2604. [PubMed]\u202f[Google Scholar]Ng V.Y., Scharschmidt T.J., Mayerson J.L., et al. Incidence and survival in sarcoma in the United States: a focus on musculoskeletal lesions. Anticancer Res. 2013;33:2597\u2013604. [PubMed].","journal-title":"Anticancer Res"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0328"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005364"},{"issue":"9","key":"e_1_3_2_5_2","first-page":"577","article-title":"The price of anticancer intervention. Secondary malignancies after radiotherapy","volume":"3","author":"Hoskin P","year":"2002","unstructured":"Hoskin P. The price of anticancer intervention. Secondary malignancies after radiotherapy. Lancet Oncol. 2002;3(9):577-578. PMID: 12233734.","journal-title":"Lancet Oncol"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050395"},{"issue":"3","key":"e_1_3_2_7_2","first-page":"405","article-title":"Intraosseous malignant peripheral nerve sheath tumor of maxilla: a case report with review of the literature","volume":"11","author":"Tamgadge S","year":"2014","unstructured":"Tamgadge S, Modak N, Tamgadge AP, Bhalerao S. Intraosseous malignant peripheral nerve sheath tumor of maxilla: a case report with review of the literature. Dent Res J (Isfahan). 2014;11(3):405-410. PMID: 25097654; PMCID: PMC4119377.","journal-title":"Dent Res J (Isfahan)"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070405"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1221"},{"key":"e_1_3_2_10_2","unstructured":"Zehr LJ Cooper JS. Mandible Osteoradionecrosis. Stat Pearls 2023. Last Update: July 17 2023."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10204704"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2013.765592"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.07.002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.57366"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3095"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.91"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2019.06.035"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1309\/UC6KQHLD9LV2KENN"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-018-0755-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31754"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241286061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241286061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241286061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:16:06Z","timestamp":1787645766000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241286061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1177\/10668969241286061"],"URL":"https:\/\/doi.org\/10.1177\/10668969241286061","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241286061\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241286061\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241286061\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241286061\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241286061\/v2\/response1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,7]]}}}