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Histopathological and immunohistochemical evaluation did not reveal classic markers of angiosarcoma, littoral cell angioma, or follicular dendritic cell sarcoma, but showed MDM2-amplification by FISH in all tumor cells as a marker for liposarcoma. The tumor showed growth limited to the spleen tissue. No MDM2-amplification was detectable in the perisplenic adipose tissue, so that infiltration of the spleen by retroperitoneal liposarcoma could be excluded. In summary, well-differentiated liposarcoma confined to the spleen was diagnosed. To the best of our knowledge, this is the first description of a primary liposarcoma of the spleen reported in the literature. Due to the local recurrence risk of liposarcomas, even after R0 resection, we recommended long-term periodic follow-up.<\/jats:p>","DOI":"10.1177\/10668969241291880","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T06:24:51Z","timestamp":1731479091000},"page":"928-934","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Liposarcoma of the Spleen: Case Report With Review of the Literature"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6321-3888","authenticated-orcid":false,"given":"Elisa M.","family":"W\u00e4chtersh\u00e4user","sequence":"first","affiliation":[{"name":"Klinikum Fulda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Klinikum Fulda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"B\u00f6hmer","sequence":"additional","affiliation":[{"name":"Klinikum Fulda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Marx","sequence":"additional","affiliation":[{"name":"University of G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Hellinger","sequence":"additional","affiliation":[{"name":"Klinikum Fulda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01995372"},{"key":"e_1_3_2_3_2","first-page":"398910","article-title":"Primary pleomorphic liposarcoma of liver: a case report and review of the literature","volume":"2013","author":"Naik PR","year":"2013","unstructured":"Naik PR, Kumar P, Kumar PV. 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