{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:30:52Z","timestamp":1787646652030,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Cooperatio program, research area SURG"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    Malignant glomus tumors are rare tumors of pericytic origin with a propensity to develop in the upper gastrointestinal tract. Hereby we demonstrate a tumor of a 20-year-old man, who presented with dysphagia and an exophytic esophageal mass. Histologic examination of the resected mass revealed a multinodular tumor in the esophageal wall composed of epithelioid cells showing nesting and monomorphic atypia, staghorn vessels and scanty stroma. Immunohistochemically, the neoplastic cells were positive for SMA, and H-caldesmon, while desmin was negative. Collagen IV and laminin decorated a dense intercellular basal membrane meshwork. RNA-sequencing using TruSight RNA Pan-Cancer Panel revealed a\n                    <jats:italic toggle=\"yes\">CARMN::NOTCH2<\/jats:italic>\n                    fusion, that is a recurrent, frequently described and so far specific genetic alteration in glomus tumors. In spite of the adjuvant chemotherapy regimens, the patient died of disseminated metastatic disease 2 years after the diagnosis. Our patient presentation and the previous reports in the literature highlight the frequently aggressive behavior of glomus tumors arising in the esophagus.\n                  <\/jats:p>","DOI":"10.1177\/10668969241291887","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T01:18:32Z","timestamp":1731287912000},"page":"987-991","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant Esophageal Glomus Tumor With\n                    <i>CARMN::NOTCH2<\/i>\n                    Fusion: An Additional Tumor Underscoring the Frequent Tendency of Esophageal Glomus Tumors for Aggressive Behavior"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1643-6233","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Pancsa","sequence":"first","affiliation":[{"name":"Bioptical Laboratory Ltd, Pilsen, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Mart\u00ednek","sequence":"additional","affiliation":[{"name":"Bioptical Laboratory Ltd, Pilsen, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Michal","sequence":"additional","affiliation":[{"name":"Bioptical Laboratory Ltd, Pilsen, Czechia"},{"name":"Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22102"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001925"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14888"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.21037\/acr-21-72"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12394"},{"key":"e_1_3_2_7_2","first-page":"287078","article-title":"A rare case of malignant glomus tumor of the esophagus","volume":"2013","author":"Bali GS","year":"2013","unstructured":"Bali GS, Hartman DJ, Haight JB, Gibson MK. A rare case of malignant glomus tumor of the esophagus. Case Rep Oncol Med. 2013;2013:287078, doi:https:\/\/doi.org\/10.1155\/2013\/287078. Epub 2013 Dec 17. PMID: 24455358; PMCID: PMC3877612.","journal-title":"Case Rep Oncol Med"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.01.092"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2019.05.08"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23022"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-012-0345-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2006.00568.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000003029"},{"issue":"2","key":"e_1_3_2_14_2","first-page":"93","article-title":"Glomus tumor of the esophagus: a case report and review of the literature","volume":"79","author":"Segura S","year":"2015","unstructured":"Segura S, Mansoor S, Gorelick AB, Sieber S, El-Fanek H. Glomus tumor of the esophagus: a case report and review of the literature. Conn Med. 2015;79(2):93-95. PMID: 26244207.","journal-title":"Conn Med"},{"issue":"51","key":"e_1_3_2_15_2","first-page":"687","article-title":"Synchronous multiple glomus tumors of the esophagus and lung","volume":"50","author":"Altorjay A","year":"2003","unstructured":"Altorjay A, Arat\u00f3 G, Adame M, et al. Synchronous multiple glomus tumors of the esophagus and lung. Hepato-gastroenterology. 2003;50(51):687-690. PMID: 12828061.","journal-title":"Hepato-gastroenterology"},{"issue":"3","key":"e_1_3_2_16_2","first-page":"133","article-title":"Glomus tumour of the oesophagus","volume":"52","author":"Papla B","year":"2001","unstructured":"Papla B, Zieli\u0144ski M. Glomus tumour of the oesophagus. Pol J Pathol. 2001;52(3):133-135. PMID: 11769400.","journal-title":"Pol J Pathol"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000913"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03575-w"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200002000-00007"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182260752"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63279-8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001531"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241291887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241291887","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241291887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:15:48Z","timestamp":1787645748000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241291887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,10]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1177\/10668969241291887"],"URL":"https:\/\/doi.org\/10.1177\/10668969241291887","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241291887\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241291887\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241291887\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241291887\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241291887\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241291887\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241291887\/v1\/review1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,10]]}}}