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However, various clinical and histologic features have been reported, including tumors in male patients, malignant transformation, extragenital sites, huge sizes, and a prominent lipomatous pattern. We report the clinical and pathologic features of one such tumor: a 23.5 cm lipomatous angiomyofibroblastoma of the vulva in a 40-year-old female patient. We also discuss important diagnostic considerations when approaching such large tumors, particularly in the setting of a biopsy specimen.<\/jats:p>","DOI":"10.1177\/10668969241291890","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T03:16:07Z","timestamp":1732072567000},"page":"921-927","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant Angiomyofibroblastoma With a Florid Lipomatous Component: A Report and Review of Diagnostic Considerations"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-1986","authenticated-orcid":false,"given":"Christopher M","family":"Sande","sequence":"first","affiliation":[{"name":"Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Jos\u00e9","family":"Err\u00e1ez-Jaramillo","sequence":"additional","affiliation":[{"name":"Instituto del Cancer, Solca N\u00facleo de Loja, Loja, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Suresh","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hicks-Courant","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos L","family":"Tanyi","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199204000-00006"},{"issue":"3","key":"e_1_3_3_3_2","first-page":"284","article-title":"Angiomyofibroblastoma of the vulva and vagina","volume":"9","author":"Nielsen GP","year":"1996","unstructured":"Nielsen GP, Rosenberg AE, Young RH, Dickersin GR, Clement PB, Scully RE. 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