{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:29:07Z","timestamp":1787646547482,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIH","award":["K08EB030120"],"award-info":[{"award-number":["K08EB030120"]}]},{"name":"NIH","award":["R01EB030130"],"award-info":[{"award-number":["R01EB030130"]}]},{"name":"NIH","award":["R01HD112302"],"award-info":[{"award-number":["R01HD112302"]}]},{"name":"NIH","award":["UG3OD035513"],"award-info":[{"award-number":["UG3OD035513"]}]},{"name":"NIH","award":["UL1TR001422"],"award-info":[{"award-number":["UL1TR001422"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background.<\/jats:italic>\n                    Widespread adoption of antiretroviral therapy has reduced perinatal transmission of HIV; however, people living with HIV (PWH) have higher rates of preterm birth and hypertensive disorders of pregnancy. The placenta is the critical fetal support organ in pregnancy, and multiple investigations have sought associations in PWH between HIV and placental pathology. However, results have been inconclusive. We posit that selection of control group populations influences the apparent anomalies in placentas from PWH and examined the differences seen between these placentas and those of four comparator populations.\n                    <jats:italic toggle=\"yes\">Methods.<\/jats:italic>\n                    Placentas from PWH were compared with those from all patients without HIV, controls from a recent study of severe acute respiratory syndrome coronavirus 2 in pregnancy, patients with a history of melanoma\u2014an indication for examination relatively orthogonal to other problems in pregnancy, and patients paired with PWH using propensity score matching.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    People living with HIV differ in demographics and comorbidities from comparator groups other than propensity score\u2013matched patients. Placentas from PWH had higher rates of acute placental inflammation, including maternal inflammatory response and fetal inflammatory response, than multiple comparator groups. Placentas from PHW had lower rates of chronic placental inflammation than three of four comparator groups, including the largest comparator group and the group matched to PWH using propensity scores.\n                    <jats:italic toggle=\"yes\">Conclusion.<\/jats:italic>\n                    Differences in placental pathology in PWH depend on the comparator group. Commonly used comparator groups have significantly different demographic and comorbidity profiles, suggesting they are inappropriate comparators for PWH. Propensity score matching may be useful in identifying comparator populations.\n                  <\/jats:p>","DOI":"10.1177\/10668969241295351","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T04:33:04Z","timestamp":1731904384000},"page":"851-860","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Defining Appropriate Comparator Populations for Placental Pathology for Pregnant People With HIV"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-057X","authenticated-orcid":false,"given":"Jeffery A.","family":"Goldstein","sequence":"first","affiliation":[{"name":"Department of Pathology, Northwestern University, Feinberg School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison D.","family":"Gernand","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Penn State College of Health and Human Development"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Ross and Carol Nese College of Nursing, Penn State College of Health and Human Development, University Park, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisheva D.","family":"Shanes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University, Feinberg School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Bebell","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Elimination of mother-to-child transmission. UNICEF DATA. Accessed November 30 2022. https:\/\/data.unicef.org\/topic\/hivaids\/emtct\/"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002824"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2021.09.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab240"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.10.003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/157016209789973628"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12858"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.06.016"},{"key":"e_1_3_3_10_2","first-page":"106689692211025","article-title":"Placental pathology after SARS-CoV-2 infection in the Pre-variant of concern, alpha \/ gamma, Delta, or omicron eras","volume":"31","author":"Shanes ED","year":"2022","unstructured":"Shanes ED, Miller ES, Otero S, et al. Placental pathology after SARS-CoV-2 infection in the Pre-variant of concern, alpha \/ gamma, Delta, or omicron eras. Int J Surg Pathol. Published online May 29, 2022;31:106689692211025. doi:https:\/\/doi.org\/10.1177\/10668969221102534","journal-title":"Int J Surg Pathol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.02.011"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa089"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/15513819609168713"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_3_3_16_2","unstructured":"NOT-OD-15-089: Racial and Ethnic Categories and Definitions for NIH Diversity Programs and for Other Reporting Purposes. Accessed October 3 2023. https:\/\/grants.nih.gov\/grants\/guide\/notice-files\/NOT-OD-15-089.html"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000247646.19979.9f"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002446"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/317634"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24680-w"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu393"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002734"},{"issue":"5","key":"e_1_3_3_23_2","first-page":"449","article-title":"Practice guideline for examination of the placenta: developed by the placental pathology practice guideline development task force of the college of American pathologists","volume":"121","author":"Langston C","year":"1997","unstructured":"Langston C, Kaplan C, Macpherson T, et al. Practice guideline for examination of the placenta: developed by the placental pathology practice guideline development task force of the college of American pathologists. Arch Pathol Lab Med. 1997;121(5):449\u2013476.","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1842869"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2749"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2012-000896"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175508"},{"key":"e_1_3_3_28_2","unstructured":"D\u2019Amour A Heller K Moldovan D et al. Underspecification presents challenges for credibility in modern machine learning. J Mach Learn Res. Published online 2020. doi:https:\/\/doi.org\/10.48550\/ARXIV.2011.03395"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.06.038"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102356"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/1093526617698600"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy167"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12197"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-020-00994-0"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32834db300"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.885837"},{"key":"e_1_3_3_37_2","unstructured":"Centers for Disease Control and Prevention. HIV Surveillance Report 2021 Vol 34. Published online May 2023. http:\/\/www.cdc.gov\/hiv\/library\/reports\/hiv-surveillance.html"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031819"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.08.015"},{"issue":"4","key":"e_1_3_3_40_2","article-title":"Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance","volume":"213","author":"Kim CJ","year":"2015","unstructured":"Kim CJ, Romero R, Chaemsaithong P, Kim JS. Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance. Am J Obstet Gynecol. 2015;213(4 Suppl):S53\u2013S69. doi:https:\/\/doi.org\/10.1016\/j.ajog.2015.08.041","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.825075"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0771-SA"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2021.02.020"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-017-0356-x"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7999"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1004"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241295351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241295351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241295351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:16:30Z","timestamp":1787645790000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241295351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1177\/10668969241295351"],"URL":"https:\/\/doi.org\/10.1177\/10668969241295351","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]}}}