{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:29:33Z","timestamp":1787646573025,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Hemosiderotic fibrolipomatous tumor (HFLT) and myxoinflammatory fibroblastic sarcoma (MIFS) are rare, locally aggressive soft tissue tumors with a predilection for distal extremities of middle-aged adults. Hybrid tumors (HFLT-MIFS) demonstrate overlapping features of both and share recurrent translocation (1;10) (p22; q24). We describe a tumor with high-grade sarcomatous transformation of a hybrid HFLT-MIFS, with a novel\n                    <jats:italic toggle=\"yes\">ADAMTS12::TERT<\/jats:italic>\n                    gene fusion, presenting as a right foot soft tissue mass in an 85-year-old woman. Histologically, the tumor showed a high-grade sarcoma with areas of hybrid HFLT-MIFS in subsequent resection. The patient was treated surgically with a below-knee amputation and interval radiation therapy. On RNA-based next-generation sequencing, the tumor harbored a novel\n                    <jats:italic toggle=\"yes\">ADAMTS12::TERT<\/jats:italic>\n                    gene fusion. In addition to reporting a novel gene fusion in a rare example of hybrid HFLT-MIFS with high-grade sarcomatous transformation, we also discuss relevant morphological features of sarcomatous HFLT and provide a brief review of reported neoplasms with\n                    <jats:italic toggle=\"yes\">TERT<\/jats:italic>\n                    gene fusions.\n                  <\/jats:p>","DOI":"10.1177\/10668969241300492","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T04:09:38Z","timestamp":1736222978000},"page":"1190-1195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["High-Grade Sarcomatous Transformation of Hybrid Hemosiderotic Fibrolipomatous Tumor-Myxoinflammatory Fibroblastic Sarcoma with Novel\n                    <i>ADAMTS12::TERT<\/i>\n                    Gene Fusion"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-6579","authenticated-orcid":false,"given":"Jatin S.","family":"Gandhi","sequence":"first","affiliation":[{"name":"Emory University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-5406","authenticated-orcid":false,"given":"Kristin K.","family":"Deeb","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4372-7560","authenticated-orcid":false,"given":"Eleanor Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-8275","authenticated-orcid":false,"given":"Anshu","family":"Bandhlish","sequence":"additional","affiliation":[{"name":"University of Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880221"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02360.x"},{"issue":"4","key":"e_1_3_2_4_2","first-page":"384","article-title":"Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin\u2019s disease, and various sarcomas","volume":"11","author":"Montgomery EA","year":"1998","unstructured":"Montgomery EA, Devaney KO, Giordano TJ, Weiss SW. Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin\u2019s disease, and various sarcomas. Modern Pathol. 1998;11(4):384-391.","journal-title":"Modern Pathol"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199808000-00001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(98)80041-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20897"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000151"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000212"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0412-RA"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2513"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000376"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f17d51"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.02.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31829ff078"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12153"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1242-7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31829f3d85"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2015.03.012"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2350\/13-06-1353-CR.1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-2835-0_9"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0062"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250518"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2021.02.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01138-z"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3781"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.02.154"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25903"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110866"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.849717"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241300492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241300492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241300492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:16:16Z","timestamp":1787645776000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241300492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/10668969241300492"],"URL":"https:\/\/doi.org\/10.1177\/10668969241300492","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241300492\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300492\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300492\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300492\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300492\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300492\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300492\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300492\/v3\/response1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}