{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:22Z","timestamp":1787646502584,"version":"build-2736575974"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Objectives<\/jats:italic>\n                    . To determine the accuracy of grading pancreatic well-differentiated neuroendocrine tumors (PanNETs) on endoscopic ultrasound-guided fine needle biopsy (EUS-FNB).\n                    <jats:italic toggle=\"yes\">Methods<\/jats:italic>\n                    . Fifty-three (53) PanNETs from 52 patients with EUS-FNB and subsequent resection were included, including 1 patient with 2 synchronous tumors biopsied separately. Grade (G) was assigned as per the 2019 World Health Organization criteria. The concordance of grade between EUS-FNB and resection was measured using kappa statistic. Clinicopathologic features were compared between specimens with concordant or discordant grading.\n                    <jats:italic toggle=\"yes\">Results<\/jats:italic>\n                    . Two-thirds of patients were male, and the median age was 62 years (range 27\u201385). Four received neoadjuvant therapy. 89% were nonfunctional, whereas 11% were functional. Concordance of grade between EUS-FNB and resection was moderate (kappa\u2009=\u20090.45). Precisely 25% (13 out of 51) of G1 or G2 specimens were discordant. G2 tumors were frequently undergraded on EUS-FNB (11 out of 18; 61%), whereas G1 tumors were only rarely overgraded (2 out of 33; 6%). Two G3 tumors were concordant. There was no correlation between concordance and other clinicopathologic features, except for perineural invasion.\n                    <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>\n                    . The concordance of PanNET grading between EUS-FNB and resection was moderate, and G2 tumors were frequently undergraded on EUS-FNB. Knowledge of this is important to recognize and acknowledge, as this could potentially impact treatment decisions in some patients.\n                  <\/jats:p>","DOI":"10.1177\/10668969241300965","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T02:43:30Z","timestamp":1736736210000},"page":"1116-1120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatic Well-Differentiated Neuroendocrine Tumors are Frequently Undergraded on Endoscopic Ultrasound-Guided Fine Needle Biopsy Sampling: A Single Institutional Experience"],"prefix":"10.1177","volume":"33","author":[{"given":"Michael","family":"Kozak","sequence":"first","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Waters","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8116-1089","authenticated-orcid":false,"given":"Brent K.","family":"Larson","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Guindi","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith K.","family":"Lai","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-0525","authenticated-orcid":false,"given":"Danielle A.","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyac049"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13975"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.08.023"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.12.015"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000499172"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001157"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09923-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2018.02.001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000477213"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12111"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061861"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005390"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001602"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-000811"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241300965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241300965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241300965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:16:13Z","timestamp":1787645773000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241300965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,12]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/10668969241300965"],"URL":"https:\/\/doi.org\/10.1177\/10668969241300965","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969241300965\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300965\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300965\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300965\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969241300965\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,12]]}}}