{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:31:03Z","timestamp":1787945463870,"version":"build-2784847793"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">DEK::AFF2<\/jats:italic>\n                    squamous cell carcinoma is a recently recognized entity characterized by a non-viral-related non-keratinizing squamous cell carcinoma with chromosomal rearrangement between\n                    <jats:italic toggle=\"yes\">DEK<\/jats:italic>\n                    on 6p22.3 and\n                    <jats:italic toggle=\"yes\">AFF2<\/jats:italic>\n                    on Xq28. This neoplasm is associated with an aggressive clinical behavior, particularly regarding local recurrences and distant metastases even with its deceptively bland histomorphology. In this article, we report on 2 patients with\n                    <jats:italic toggle=\"yes\">DEK<\/jats:italic>\n                    ::\n                    <jats:italic toggle=\"yes\">AFF2<\/jats:italic>\n                    squamous cell carcinomas, which were only diagnosed at the time of recurrence. Patient #1 was originally misdiagnosed with inverted papilloma. This occurred 3 years previously, and at second presentation the tumor was recurrent in the nasal cavity and paranasal sinuses. Patient #2 was identified at second recurrence of a \u201cnasopharyngeal carcinoma,\u201d initially diagnosed in the nasopharynx 5 years earlier, with a subsequent recurrence in the middle ear 2 years later, involving the mastoid process. The immunophenotypic and molecular work-up, as well as the management of these patients, are discussed. In our review of the English-language literature on\n                    <jats:italic toggle=\"yes\">DEK<\/jats:italic>\n                    ::\n                    <jats:italic toggle=\"yes\">AFF2<\/jats:italic>\n                    squamous cell carcinomas, we identified 41 patients, including our 2 patients. Of these, 26 had information on their clinical course. Sixty-nine percent of patients reported a history of locoregional recurrence, and 19% reported a history of distant metastases, with an average follow-up duration of 36 months after multimodality therapies. Given our improved understanding of\n                    <jats:italic toggle=\"yes\">DEK<\/jats:italic>\n                    ::\n                    <jats:italic toggle=\"yes\">AFF2<\/jats:italic>\n                    squamous cell carcinoma as an aggressive tumor, it is crucial to differentiate this neoplasm from other potential histomorphologic mimickers to ensure early and accurate diagnosis.\n                  <\/jats:p>","DOI":"10.1177\/10668969241301061","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T10:34:23Z","timestamp":1737110063000},"page":"1258-1266","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>DEK::AFF2<\/i>\n                    Squamous Cell Carcinomas of the Sinonasal Region and Temporal Bone Diagnosed After Recurrences: A Report of Two Patients"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-9469","authenticated-orcid":false,"given":"Adepitan A.","family":"Owosho","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, College of Medicine, The University of Tennessee Health Sciences Center, Memphis, TN, USA"},{"name":"Department of Diagnostic Sciences, College of Dentistry, The University of Tennessee Health Sciences Center, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Gleysteen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, College of Medicine, The University of Tennessee Health Sciences Center, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Burton","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, College of Medicine, The University of Tennessee Health Sciences Center, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Franklin","sequence":"additional","affiliation":[{"name":"College of Medicine, The University of Tennessee Health Sciences Center, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Angel","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, College of Medicine, The University of Tennessee Health Sciences Center, Memphis, TN, USA"},{"name":"Methodist Le Bonheur Healthcare"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0434-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00846-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01117-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2022.05.009"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001498"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001596"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001741"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03717-0"},{"issue":"1","key":"e_1_3_2_10_2","first-page":"67","article-title":"A diagnostic algorithm for sinonasal papillary non-keratinizing squamous cell carcinoma with DEK::AFF2 fusion and mimickers","volume":"57","author":"Laforga JB","year":"2024","unstructured":"Laforga JB, Othman BK. A diagnostic algorithm for sinonasal papillary non-keratinizing squamous cell carcinoma with DEK::AFF2 fusion and mimickers. Rev Esp Patol. 2024;57(1):67\u201370.","journal-title":"Rev Esp Patol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-023-01594-2"},{"issue":"10","key":"e_1_3_2_12_2","first-page":"1058","article-title":"[Primary DEK::AFF2 fusion positive nonkeratinizing squamous cell carcinoma of the middle ear: report of a case]","volume":"52","author":"Yu ST","year":"2023","unstructured":"Yu ST, Ye XZ, Xu BQ, et al. [Primary DEK::AFF2 fusion positive nonkeratinizing squamous cell carcinoma of the middle ear: report of a case]. Zhonghua Bing Li Xue Za Zhi. 2023;52(10):1058\u20131060.","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-023-01538-w"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-024-01466-5"},{"issue":"1","key":"e_1_3_2_15_2","article-title":"DEK::AFF2 fusion-associated sinonasal carcinoma: a challenging entity mimicking sinonasal papilloma","volume":"160","author":"Bishop J","year":"2023","unstructured":"Bishop J, Amin SE, Naik U, Ahmed AA, Saluja K, Bridge J. DEK::AFF2 fusion-associated sinonasal carcinoma: a challenging entity mimicking sinonasal papilloma. Am J Clin Pathol. 2023;160(Suppl 1):S61\u2013S62.","journal-title":"Am J Clin Pathol"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000376"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S173056"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000460"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0808-z"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241301061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241301061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241301061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:16:18Z","timestamp":1787645778000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241301061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,17]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/10668969241301061"],"URL":"https:\/\/doi.org\/10.1177\/10668969241301061","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,17]]}}}