{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:22Z","timestamp":1787646502577,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Objective.<\/jats:italic>\n                    The presence of high tumor budding in colorectal carcinomas is a significant pathological feature indicative of a high potential for lymph node metastasis. Our aim was to investigate the prognostic impact of tumor budding in ampullary carcinomas.\n                    <jats:italic toggle=\"yes\">Materials and methods.<\/jats:italic>\n                    We conducted a cohort of 101 consecutive ampullary carcinoma resections to evaluate tumor budding, macroscopic and microscopic subtypes, lymphatic\/vascular\/perineural invasions, and other histopathological parameters.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    High tumor budding was observed in 49 (49%) of the tumors, and multivariate survival analysis evaluating the overall survival of these patients found tumor budding to be an independent poor prognostic indicator (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.013).\n                    <jats:italic toggle=\"yes\">Conclusion.<\/jats:italic>\n                    Tumor budding should be reported in ampullary carcinomas as it serves as an independent predictor of a poor outcome.\n                  <\/jats:p>","DOI":"10.1177\/10668969241308204","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:13:39Z","timestamp":1736727219000},"page":"1135-1141","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Significance of Tumor Budding in Ampullary Carcinomas"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-1166","authenticated-orcid":false,"given":"Kadriye Ebru","family":"Akar","sequence":"first","affiliation":[{"name":"Marmara University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Bagci","sequence":"additional","affiliation":[{"name":"Marmara University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_3_2_3_2","volume-title":"Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract, and pancreas","author":"Odze RD","year":"2015","unstructured":"Odze RD, Goldblum JR. Odze and Goldblum surgical pathology of the GI tract, liver, biliary tract, and pancreas. 3th ed. Saunders\/Elsevier; 2015.","edition":"3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.08.007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000504"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.46"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24946"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000165"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826399d8"},{"key":"e_1_3_2_10_2","unstructured":"Balc\u0131 S. 2024. 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