{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:04:08Z","timestamp":1787828648564,"version":"build-2784847793"},"reference-count":9,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Keratin positive giant cell rich tumor is a rare mesenchymal tumor first described in 2020. It can occur in both soft tissue and bone and predominantly affects young women. The tumor's biological behavior remains uncertain despite its low-grade classification. Characterized by keratin expression and a\n                    <jats:italic toggle=\"yes\">HMGA2::NCOR2<\/jats:italic>\n                    gene fusion, keratin positive giant cell rich tumors resemble conventional giant cell tumors but lacks\n                    <jats:italic toggle=\"yes\">H3-3A<\/jats:italic>\n                    gene mutations. This article presents a 31-year-old woman with a keratin positive giant cell rich tumor in the pelvic bone, detailing her clinical presentation, diagnostic process, treatment, and postoperative recovery. Histological examination revealed numerous osteoclast-like giant cells within a mononuclear stroma, with RNA sequencing confirming the\n                    <jats:italic toggle=\"yes\">HMGA2::NCOR2<\/jats:italic>\n                    fusion. The patient's management included surgical resection, with no recurrence at six months follow-up. The discussion emphasizes the need for further research to understand keratin positive giant cell rich tumors pathogenesis and explore potential targeted therapies.\n                  <\/jats:p>","DOI":"10.1177\/10668969241308224","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T04:42:31Z","timestamp":1736311351000},"page":"1267-1270","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Keratin Positive Giant Cell Rich Tumor of the Pelvic Bone with a\n                    <i>HMGA2::NCOR2<\/i>\n                    Fusion: A Case Report"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-9776","authenticated-orcid":false,"given":"Lise","family":"Geuens","sequence":"first","affiliation":[{"name":"UZ Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raf","family":"Sciot","sequence":"additional","affiliation":[{"name":"UZ Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Vanden Bempt","sequence":"additional","affiliation":[{"name":"UZ Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Douchy","sequence":"additional","affiliation":[{"name":"UZ Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedl","family":"Sinnaeve","sequence":"additional","affiliation":[{"name":"UZ Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Wafa","sequence":"additional","affiliation":[{"name":"UZ Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0562-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00789-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.21873\/cgp.20312"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01115-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2023.07.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/2056-4538.12376"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.03.020"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01210-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.11.006"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241308224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969241308224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969241308224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:16:06Z","timestamp":1787645766000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969241308224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/10668969241308224"],"URL":"https:\/\/doi.org\/10.1177\/10668969241308224","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]}}}