{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:31:12Z","timestamp":1787646672453,"version":"build-2736575974"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"JSPS KAKENHI","award":["JP20K07405"],"award-info":[{"award-number":["JP20K07405"]}]},{"DOI":"10.13039\/501100003806","name":"Hokuto Foundation for Bioscience","doi-asserted-by":"publisher","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/501100003806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    IgG4-related disease (IgG4-RD) is an autoimmune disease of unknown cause.\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    is a transcription factor involved in immune responses, and its dysfunction leads to uncontrolled immune responses. We performed, to our knowledge, the first\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    methylation analysis in type 1 autoimmune pancreatitis (denoted simply as AIP), a representative IgG4-RD. We conducted methylation array analysis on AIP samples using the Illumina Infinium MethylationEPIC array. We identified a potentially important\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    methylation abnormality in AIP, which was further confirmed using the quantitative SYBR green methylation-specific polymerase chain reaction (QSG-MSP) method. Using immunohistochemistry, we analyzed\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    expression in lymphocytes in 11 lymph nodes with AIP (LN-AIP) and 20 lymph nodes with pancreatic ductal adenocarcinoma (PDA; LN-PDA). LN-AIP and LN-PDA refer to lymph nodes from patients with AIP and PDA, respectively. All selected PDA patients lacked lymph node metastases. By array analysis,\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    was more highly methylated in LN-AIP than in LN-PDA (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.0275).\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    was also more highly methylated in LN-AIP than in LN-PDA by QSG-MSP validation (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.0331). Immunohistochemical analysis indicated that\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    expression was significantly lower in LN-AIP than in LN-PDA (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.0250). Aberrant\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    methylation and reduced expression may be characteristic of AIP. Further validation is warranted.\n                  <\/jats:p>","DOI":"10.1177\/10668969241308227","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:12:48Z","timestamp":1736727168000},"page":"1121-1127","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Aberrant Methylation of\n                    <i>RUNX1<\/i>\n                    is Associated with the Pathogenesis of Autoimmune Pancreatitis"],"prefix":"10.1177","volume":"33","author":[{"given":"Yasuhiro","family":"Kinugawa","sequence":"first","affiliation":[{"name":"Ichinomiya Nishi Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7694-9015","authenticated-orcid":false,"given":"Takeshi","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Iwaya","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Asaka","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan"},{"name":"Department of Laboratory Medicine, Nagano Children's Hospital, Azumino, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanobu","family":"Nagaya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan"},{"name":"Department of Biomedical Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90087-6"},{"issue":"4","key":"e_1_3_4_4_2","article-title":"IgG4-related disease: pathophysiologic insights drive emerging treatment approaches","volume":"34","author":"Stone JH","year":"2016","unstructured":"Stone JH. IgG4-related disease: pathophysiologic insights drive emerging treatment approaches. 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