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Magnetic resonance imaging (MRI) performed two months prior to the surgery showed only the presence of a neoplasm. However, a repeat MRI in the immediate pre-operative period revealed an additional, likely fungal, lesion. During this interval of 2 months, the patient had received a short course of steroids for suspected encephalitis. The steroid therapy and the CNS tropism of the fungi could have contributed to the CNS mycosis. The intratumoral localization of the fungi could be attributed either to the altered tumour vasculature or to a mere coincidence. Occurrence of CNS mycosis within a high grade glioma is exceedingly rare. A majority of such patients reported in the literature had received chemotherapy for the glioma.<\/jats:p>","DOI":"10.1177\/10668969241308233","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:12:56Z","timestamp":1736727176000},"page":"1288-1292","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An Intratumoral Phaeohyphomycotic Abscess in a Chemotherapy-Naive IDH-Mutant Glioma: A Mere Coincidence?"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-5534","authenticated-orcid":false,"given":"Rajalakshmi","family":"Poyuran","sequence":"first","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesavadas","family":"Chandrasekharan","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Vilanilam","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Narasimhaiah","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/380635"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-10"},{"issue":"2","key":"e_1_3_3_4_2","first-page":"87","article-title":"Sudden death secondary to fulminant intracranial aspegillosis in a healthy teenager after posterior fossa surgery: the role of corticosteroids and prophylactic recommendations","volume":"48","author":"Dickerman RD","year":"2004","unstructured":"Dickerman RD, Stevens QEJ, Schneider SJ. 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Aspergillosis of the central nervous system in glioblastoma multiforme. Neurochirurgia (Stuttg). 1991;34(4):119-124. doi:https:\/\/doi.org\/10.1055\/s-2008-1052069","journal-title":"Neurochirurgia (Stuttg)"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox175"},{"issue":"3","key":"e_1_3_3_12_2","first-page":"547","article-title":"Temozolomide-related infections: review of the literature","volume":"16","author":"Kizilarslanoglu MC","year":"2011","unstructured":"Kizilarslanoglu MC, Aksoy S, Yildirim NO, Ararat E, Sahin I, Altundag K. Temozolomide-related infections: review of the literature. 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