{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:29:43Z","timestamp":1787646583920,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    The combination of ependymoma and gliosarcoma elements in the same tumor is extremely rare, and the molecular characteristics of these entities are not clear. Here, we present a rare aggressive brain tumor in a 12-year-old boy harboring a\n                    <jats:italic toggle=\"yes\">ZFTA::RELA<\/jats:italic>\n                    gene fusion, a characteristic feature of supratentorial ependymomas. On the other hand, the histopathological, molecular, and methylation profiles were compatible with a diagnosis of a mesenchymal type, IDH wild-type glioblastoma multiforme (GBM). Additional somatic alterations provide evidence of RAS\/MAPK signaling pathway activation. Overall, this report highlights the histopathological and molecular characteristics of a rare and aggressive glial tumor.\n                  <\/jats:p>","DOI":"10.1177\/10668969241311520","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:43:01Z","timestamp":1738312981000},"page":"1450-1453","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Characteristics of a\n                    <i>ZFTA::RELA<\/i>\n                    Fusion Gliosarcoma: A Case Report"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-8315","authenticated-orcid":false,"given":"Tzah","family":"Feldman","sequence":"first","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Vlodavsky","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shada","family":"Sarji","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa Yousef","family":"Abu El Hija","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony","family":"Benifla","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Oren","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Ben-Arush","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Zohar","sequence":"additional","affiliation":[{"name":"Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2008-076"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.034"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97454-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-019-03184-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12770"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318158234e"},{"issue":"1","key":"e_1_3_2_9_2","article-title":"Sarcomatous change of cerebellopontine angle ependymoma following radiosurgery: a case report","volume":"14","author":"Dadario NB","year":"2022","unstructured":"Dadario NB, Pruitt R, Silverstein JW, et al. Sarcomatous change of cerebellopontine angle ependymoma following radiosurgery: a case report. 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