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Although uncommon, it is important to consider when a neoplasm with osteoclast-like giant cells is encountered. In this report, we describe a 70-year-old female patient with an unremarkable past history who presented with an enlarged uterus. Transvaginal ultrasound demonstrated multiple fibroids and a thickened endometrium. A biopsy diagnosis of a highgrade sarcoma was rendered and further refined in the surgical resection as malignant giant cell tumor of the uterus. In this case report, we describe the findings of this case and discuss the differential diagnosis of this entity.<\/jats:p>","DOI":"10.1177\/10668969241312402","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T22:06:48Z","timestamp":1738102008000},"page":"1467-1472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant Cell Tumor of the Uterus: A Report and Review of the Literature"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5274-4114","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Martins Gama","sequence":"first","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Coimbra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Trent","family":"Fry","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-3477","authenticated-orcid":false,"given":"Charles Matthew","family":"Quick","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.07.090"},{"key":"e_1_3_2_3_2","volume-title":"WHO Classification of Soft Tissue and Bone Tumours","author":"IARC","year":"2020","unstructured":"IARC WHO Classification of Soft Tissue and Bone Tumours. 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