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The patient was 61-year-old with a cauliflower-like tumor of the glans penis of less than 1-year duration. Microscopic examination revealed a p16-negative well-differentiated squamous proliferation characterized by narrow and cystic spaces extending through the lesion. Carcinoma cuniculatum is characterized by a strong tendency to deep penetration, typically presenting in patients in their seventh to eighth decades and with a long duration of the disease. In contrast, the tumor presented herein occurred in a younger patient with a shorter disease duration and showed only shallow growth into the underlying structures. Since penile carcinoma cuniculatum is a local disease without metastatic potential (regardless of tumor size and disease duration), awareness of this entity is important, especially for distinguishing it from other more aggressive subtypes of squamous cell carcinoma, which require different therapeutic approaches.<\/jats:p>","DOI":"10.1177\/10668969251314121","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T23:56:41Z","timestamp":1738886201000},"page":"1477-1483","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Penile Carcinoma Cuniculatum: A Case Report of an Extremely Rare Subtype of Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-5538","authenticated-orcid":false,"given":"Ji\u0159\u00ed","family":"Lenz","sequence":"first","affiliation":[{"name":"Znojmo Hospital"},{"name":"Cytohisto s.r.o., B\u0159eclav, Czech Republic"},{"name":"University of Veterinary and Pharmaceutical Sciences Brno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kv\u011btoslava","family":"Michalov\u00e1","sequence":"additional","affiliation":[{"name":"Bioptical Laboratory, Ltd., Pilsen, Czech Republic"},{"name":"Faculty of Medicine in Pilsen, Charles University, Pilsen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lud\u011bk","family":"Fiala","sequence":"additional","affiliation":[{"name":"Cytohisto s.r.o., B\u0159eclav, Czech Republic"},{"name":"Faculty of Medicine in Pilsen, Charles University, Pilsen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Tich\u00fd","sequence":"additional","affiliation":[{"name":"Masaryk Memorial Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franti\u0161ek","family":"Tich\u00fd","sequence":"additional","affiliation":[{"name":"University of Veterinary and Pharmaceutical Sciences Brno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"N\u011bmcov\u00e1","sequence":"additional","affiliation":[{"name":"Bioptical Laboratory, Ltd., Pilsen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Kavka","sequence":"additional","affiliation":[{"name":"Znojmo Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2014.02.art2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59831-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23743"},{"key":"e_1_3_2_5_2","volume-title":"Urinary and Male Genital Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022","unstructured":"WHO Classification of Tumours Editorial Board. 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