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This progress is also leading to the discovery of more new molecular agents to block those drivers, which has significantly improved cancer patient survival, especially in non-small cell lung cancer (NSCLC). However, in about 25% of NSCLC tumors molecular drivers are not yet known. Herein, we present a poorly differentiated carcinoma involving lung and mediastinum. Next generation sequencing-based RNAseq identified a novel fusion,\n                    <jats:italic toggle=\"yes\">CLTC::RPS6KB1<\/jats:italic>\n                    , while no other known drivers were present.\n                  <\/jats:p>","DOI":"10.1177\/10668969251323935","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T02:33:16Z","timestamp":1742178796000},"page":"1526-1530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel\n                    <i>CLTC::RPS6KB1<\/i>\n                    Fusion in a Poorly Differentiated Carcinoma Involving the Lung and Mediastinum"],"prefix":"10.1177","volume":"33","author":[{"given":"Mitchell","family":"Zhao","sequence":"first","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1242-3014","authenticated-orcid":false,"given":"Nicholas","family":"Protopsaltis","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Sabet","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulei","family":"Sun","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Lin","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Hasteh","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-24100-1_2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.03.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph16071004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.11.020"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2017.1294273"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22552"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2023.728"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01497-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.15.1252"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00390"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.6.3725"},{"key":"e_1_3_2_13_2","article-title":"Lung adenocarcinoma genomics","author":"Meyerson M","year":"2012","unstructured":"Meyerson M, Govindan R, Baylin S. Lung adenocarcinoma genomics. TCGA 2nd Annual Symposium. Published online November 28, 2012. 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