{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:46Z","timestamp":1787646526267,"version":"build-2736575974"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    Perivascular epithelioid cell tumor (PEComa) belongs to a family of rare mesenchymal neoplasms that share characteristic morphologic, immunohistochemical and molecular findings. In this report, we provide a detailed clinicopathological characterization of a PEComa incidentally discovered in the right lung of a 53-year-old woman. This tumor with epithelioid cell morphology and myomelanocytic differentiation demonstrated a\n                    <jats:italic toggle=\"yes\">TFE3::YAP1<\/jats:italic>\n                    fusion by targeted RNA sequencing. While a subset of PEComas shows\n                    <jats:italic toggle=\"yes\">TFE3<\/jats:italic>\n                    rearrangements, fusion with\n                    <jats:italic toggle=\"yes\">YAP1<\/jats:italic>\n                    has not been systematically documented in this entity. Clear cell stromal tumor of the lung and epithelioid hemangioendothelioma characteristically display the\n                    <jats:italic toggle=\"yes\">TFE3::YAP1<\/jats:italic>\n                    fusion; however, as currently defined, both lack myomelanocytic features. Here, we describe a novel\n                    <jats:italic toggle=\"yes\">TFE3<\/jats:italic>\n                    fusion partner that further expands the spectrum of molecular alterations seen in PEComa.\n                  <\/jats:p>","DOI":"10.1177\/10668969251323936","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T17:42:41Z","timestamp":1741887761000},"page":"1519-1525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Perivascular Epithelioid Cell Tumor of the Lung With a Novel\n                    <i>YAP1::TFE3<\/i>\n                    Fusion"],"prefix":"10.1177","volume":"33","author":[{"given":"William","family":"MacDonald","sequence":"first","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Avenarius","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Aziz","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Guo","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond M.","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Satturwar","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-3130","authenticated-orcid":false,"given":"Konstantin","family":"Shilo","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2289"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-019-0612-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a9cd6c"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000502"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","unstructured":"\u201cMalignant\u201d Perivascular Epithelioid Cell Neoplasm: Risk Stratification and Treatment Strategies - Bleeker - 2012 - Sarcoma - Wiley Online Library. 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