{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:18:24Z","timestamp":1787649504642,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    As most biopsy specimens are diagnosed by interpretation of glass slides, the diagnostic process is heavily reliant on subjective interpretation. Granular cell tumors have a widely reported incidence of a pathological phenomenon termed pseudoepitheliomatous hyperplasia.\n                    <jats:bold>Aim:<\/jats:bold>\n                    The study's primary focus was to determine the incidence of pseudoepitheliomatous hyperplasia in granular cell tumors in adults using a novel definition.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A review of the existing literature provided a foundation for a novel definition of pseudoepitheliomatous hyperplasia. Two oral pathology laboratories\u2019 archived material were queried to yield 70 specimens matching inclusion criteria. Two board certified Oral and Maxillofacial Pathologists were employed as observers, calibrated on the novel definition using control specimens, and then a blind review was performed. Statistical analyses were performed via Kappa statistical agreement and Fischer's 2-way exact tests.\n                    <jats:bold>Results:<\/jats:bold>\n                    Use of the novel definition resulted in agreement in 97.4% of specimens. The Kappa agreement was 0.939 with a standard error of 0.043 and a 95% confidence interval from 0.856 to 1.0. Landis and Koch's standards for strength of agreement was \u201calmost perfect.\u201d Pseudoepitheliomatous hyperplasia was found at a rate of 36.8%. Women made up 79.4% of the study population and the average age was 45 years. Intraorally 91.8% of lesions occurred on the tongue and buccal mucosa. And 93.30% of lateral tongue granular cell tumors occurred in women.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Using a definition prior to evaluating subjective histologic criteria resulted in \u201calmost perfect\u201d interobserver statistical reliability. Our definition of pseudoepitheliomatous hyperplasia proved to be reliable and should be further tested.\n                  <\/jats:p>","DOI":"10.1177\/10668969251327743","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T03:47:33Z","timestamp":1742788053000},"page":"1563-1569","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of Pseudoepitheliomatous Hyperplasia in Oral Granular Cell Tumors of Adults: An Independent Retrospective Analysis Utilizing a Novel Definition"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0284-2813","authenticated-orcid":false,"given":"Austin J.","family":"Davies","sequence":"first","affiliation":[{"name":"University of the Pacific Arthur A. Dugoni School of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren P.","family":"Cox","sequence":"additional","affiliation":[{"name":"University of the Pacific Arthur A. Dugoni School of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo J.","family":"Padilla","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill Adams School of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Dermatology: 2-Volume set","author":"Rapini RP","year":"2007","unstructured":"Rapini RP, Bolognia JL, Jorizzo JL. Dermatology: 2-Volume set, 1st ed. Mosby; 2007.","edition":"1"},{"issue":"5","key":"e_1_3_2_3_2","article-title":"Granular cell tumor: report of 8 intraoral cases","volume":"11","author":"Eguia A","year":"2006","unstructured":"Eguia A, Uribarri A, Gay Escoda C, Crovetto MA, Martinez-Conde R, Aguirre JM. Granular cell tumor: report of 8 intraoral cases. Med Oral Patol Oral Cir Bucal. 2006;11(5):E425-E428.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"11","key":"e_1_3_2_4_2","first-page":"1070","article-title":"Malignant granular cell tumor","volume":"111","author":"Klima M","year":"1987","unstructured":"Klima M, Peters J. Malignant granular cell tumor. Arch Pathol Lab Med. 1987;111(11):1070-1073.","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(89)90718-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2008.01100.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.97690"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492012000200014"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2012.45.3.196"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.02.005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.41.12.927"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90357-X"},{"issue":"3","key":"e_1_3_2_13_2","first-page":"302","article-title":"Origin of granules in granular cell tumor. Intracellular myelin formation with autodigestion","volume":"112","author":"Mittal KR","year":"1988","unstructured":"Mittal KR, True LD. Origin of granules in granular cell tumor. Intracellular myelin formation with autodigestion. Arch Pathol Lab Med. 1988;112(3):302-303.","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780600589065"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930130405"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(79)80008-3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00725.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00371-8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-771-GCTIAO"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00454.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31821816ab"},{"key":"e_1_3_2_22_2","first-page":"260","volume-title":"Diagnostic surgical pathology of the head and neck","author":"Gnepp D","year":"2009","unstructured":"Gnepp D. Diagnostic surgical pathology of the head and neck, 2nd ed. Saunders\/Elseveir; 2009:260.","edition":"2"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.06.044"},{"issue":"5","key":"e_1_3_2_24_2","first-page":"360","article-title":"Understanding interobserver agreement: the kappa statistic","volume":"37","author":"Viera AJ","year":"2005","unstructured":"Viera AJ, Garrett JM. Understanding interobserver agreement: the kappa statistic. Fam Med. 2005;37(5):360-363.","journal-title":"Fam Med"},{"issue":"2","key":"e_1_3_2_25_2","first-page":"97","article-title":"A clinico-pathologic study of 50 adult oral granular cell tumors","volume":"39","author":"Chaudhry AP","year":"1984","unstructured":"Chaudhry AP, Jacobs MS, SunderRaj M, Yamane GM, Jain R, Scharlock SE. A clinico-pathologic study of 50 adult oral granular cell tumors. J Oral Med. 1984;39(2):97-103. 118.","journal-title":"J Oral Med"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251327743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969251327743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251327743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:19:22Z","timestamp":1787645962000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969251327743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/10668969251327743"],"URL":"https:\/\/doi.org\/10.1177\/10668969251327743","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]}}}